지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 217 - 224 (8page)
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초록· 키워드
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Background/Aims: Despite the well-established efficacy of tumor necrosis factor (TNF) antagonists as treatment options for Crohn’s disease, many pediatric patients need a change in therapy due to adverse events and loss of response, highlighting the necessity for medications with a different mechanism of action. Ustekinumab has been shown to be effective in inducing clini- cal remission in some adults with disease refractory to anti-TNF agents, however, minimal data exists in the pediatric popula- tion. Methods: We conducted a retrospective chart review of 11 pediatric patients receiving ustekinumab, specifically extract- ing baseline data, information on prior treatment and response, indications for starting ustekinumab, clinical information, and laboratory parameters pre- and post-therapy. Clinical response was defined as a decrease in abbreviated Pediatric Crohn’s Disease Activity Index score. Results: Patients ranged from 12 to 17 years of age upon initiation of treatment with ustekinumab. Five of 11 patients demonstrated a clinical response. Among these patients, 2 remained in clinical remission, while the remain- ing 3 experienced a secondary loss of response. The other 6 patients were primary nonresponders who either remained unwell or demonstrated slight clinical worsening. All patients who clinically responded to ustekinumab and had an initially elevated CRP experienced complete normalization of their values. Mucosal healing was seen on endoscopy in 1 responder, with 2 other patients showing endoscopic improvement. Conclusions: These results demonstrate for the first time that ustekinumab has the potential to induce not only clinical and biochemical remission, but also endoscopic improvement, in the pediatric popula- tion. Future research is needed to determine factors that influence response to therapy.
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참고문헌 (28)
참고문헌 신청
Burisch J / 2013 / Inflammatory bowel disease epidemiology / Curr Opin Gastroenterol 29:357~362
Benchimol EI / 2011 / Epidemiology of pediatric inflammatory bowel disease : a systematic review of international trends / Inflamm Bowel Dis 17:423~439
Kim SC / 2004 / Inflammatory bowel diseases in pediatric and adolescent patients: clinical, therapeutic, and psychosocial considerations / Gastroenterology 126:1550~1560
Jakobsen C / 2011 / Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease : a population-based study / Aliment Pharmacol Ther 34:1217~1224
Hyams JS / 2009 / Long-term outcome of maintenance infliximab therapy in children with Crohn’s disease / Inflamm Bowel Dis 15:816~822
Benchimol EI / 2011 / Epidemiology of pediatric inflammatory bowel disease : a systematic review of international trends / Inflamm Bowel Dis 17:423~439
Kim SC / 2004 / Inflammatory bowel diseases in pediatric and adolescent patients: clinical, therapeutic, and psychosocial considerations / Gastroenterology 126:1550~1560
Jakobsen C / 2011 / Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease : a population-based study / Aliment Pharmacol Ther 34:1217~1224
Hyams JS / 2009 / Long-term outcome of maintenance infliximab therapy in children with Crohn’s disease / Inflamm Bowel Dis 15:816~822
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