Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in ApcMin/+ Mice: Relation to Metabolism and Gut Microbiota Composition

Yi-Wen Huang; Chien-Wei Lin; Pan Pan; Carla Elena Echeveste; Athena Dong; Kiyoko Oshima; Martha Yearsley; Jianhua Yu; Li-Shu Wang

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자료유형: 학술저널

저자정보: Yi-Wen Huang (Medical College of Wisconsin) Chien-Wei Lin (Medical College of Wisconsin) Pan Pan (Medical College of Wisconsin) Carla Elena Echeveste (Medical College of Wisconsin) Athena Dong (Medical College of Wisconsin) Kiyoko Oshima (Johns Hopkins University) Martha Yearsley (The Ohio State University) Jianhua Yu (City of Hope National Medical Center and Beckman Research Institute) Li-Shu Wang (Medical College of Wisconsin)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제26권 제1호

발행연도: 2021.1

수록면: 32 - 40 (9page)

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Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and gut microbiota profiling in a colorectal cancer mouse model (ApcMin/+). Ffar2 deficiency promoted colonic polyp development and enhanced fatty acid oxidation and bile acid metabolism. Gut microbiome sequencing analysis showed distinct clustering among wild-type, ApcMin/+, and ApcMin/+-Ffar2-/- mice. The relative abundance of Flavobacteriaceae and Verrucomicrobiaceae was significantly increased in the ApcMin/+-Ffar2-/- mice compared to the ApcMin/+ mice. In addition, knocking-down FFAR2 in the human colon cancer cell lines (SW480 and HT29) resulted in increased expression of several key enzymes in fatty acid oxidation, such as carnitine palmitoyltransferase 2, acyl-CoA dehydrogenase, longchain acyl-CoA dehydrogenase, C-2 to C-3 short chain, and hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, alpha subunit. Collectively, these results demonstrated that Ffar2 deficiency significantly altered profiles of fatty acid metabolites and gut microbiome, which might promote colorectal cancer development.

#Ffar2 #ApcMin/+ #Colorectal cancer #Metabolomics #Gut microbiota

참고문헌 (47)

참고문헌 신청

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Pan P / 2019 / Diet and colon : what matters / Curr Opin Gastroenterol 35:101~106

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