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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root. Methods: We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APCMIN/+ (APCMIN) mouse, a genetic model of colorectal cancer. APCMIN and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0.12% ARE (Anthocyanin rich-extract prepared from SL222 sweet potato at a concentration equivalent to the flesh-supplemented diet) or a control diet (AIN-76A) for 18 weeks. At 120 days of age, the mice were anaesthetised, and blood samples were collected before the mice were sacrificed. The intestines were used for adenoma enumeration. Results: The SL222 sweet potato-supplemented diets reduced the adenoma number in the APCMIN mice. Conclusions: These data have significant implications for the use of this sweet potato variant in protection against colorectal cancer.
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참고문헌 (48)
참고문헌 신청
Beckett EL / 2014 / The role of vitamins and minerals in modulating the expression of microRNA / Nutr Res Rev 27:94~106
Caldararo N / 2012 / The Maori, behavior, modern diets and colorectal cancers / Asian Pac J Cancer Prev 13:1711~1712
Blair V / 2013 / Cancer in Māori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand / ANZ J Surg 83:42~48
Dickson G / 2010 / The prevalence of colorectal adenomas in Maori and New Zealand Europeans parallels colorectal cancer rates / N Z Med J 123:45~49
Ministry of Health / 2012 / Cancer: new registrations and deaths 2012
Caldararo N / 2012 / The Maori, behavior, modern diets and colorectal cancers / Asian Pac J Cancer Prev 13:1711~1712
Blair V / 2013 / Cancer in Māori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand / ANZ J Surg 83:42~48
Dickson G / 2010 / The prevalence of colorectal adenomas in Maori and New Zealand Europeans parallels colorectal cancer rates / N Z Med J 123:45~49
Ministry of Health / 2012 / Cancer: new registrations and deaths 2012
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