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논문 기본 정보

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저자정보
Ga Hee Kim (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Young Soo Park (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) 정기욱 (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Mimi Kim (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Hee Kyong Na (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Ji Yong Ahn (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Jeong Hoon Lee (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Do Hoon Kim (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Kee Don Choi (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Ho June Song (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Gin Hyug Lee (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig) Evan S Dellon (Center for Esophageal Diseases and Swallowing Department of Medicine University of North Carolina S) Hwoon-Yong Jung (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Asan Dig)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.4
발행연도
2019.1
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525 - 533 (9page)

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Background/Aims The epidemiology and pathogenesis of eosinophilic esophagitis (EoE) remain unclear in Asian countries. We investigated clinicopathological characteristics and diagnostic trends of EoE, and evaluated 3 tissue biomarkers for correlation with disease activity and treatment response in Korean patients with EoE. Methods We retrospectively reviewed 25 271 esophageal biopsies performed during upper endoscopies between 2006 and 2017. We diagnosed EoE based on ≥ 15 eosinophils/high-power field (HPF) and, symptoms of esophageal dysfunction. We performed immunohistochemical analysis for tryptase, eosinophilic derived neurotoxin (EDN), and eotaxin-3. Results We diagnosed EoE in 72 patients (53 men and 19 women; mean age, 46.2 years) with presenting symptoms of, dysphagia (15.3%), epigastric pain (31.9%), and heartburn (30.6%). The diagnostic rate of EoE considerably increased between 2006 and 2017, from 0.29 diagnoses to 7.99 diagnoses per 1000 esophageal biopsies (P < 0.001). The mean peak eosinophil count (PEC) was 56.0 (± 77.8)/HPF. Whereas the EDN (rho = 0.667, P < 0.001) and eotaxin-3 levels (rho = 0.465, P < 0.001) correlated with PEC, tryptase and PEC were weakly correlated (rho = 0.291, P = 0.013). EDN (rho = 0.279, P = 0.017), and tryptase (rho = 0.279, P = 0.033) correlated with the inflammatory score of Eosinophilic Esophagitis Endoscopic Reference Score. Immunohistochemical analysis and changes in tryptase, EDN, and eotaxin-3 levels were associated with histologic and endoscopic improvements. Conclusions EoE incidence considerably increased during the 12-year period, regardless of endoscopic esophageal biopsy rate. Tryptase, EDN, and eotaxin-3 levels in esophageal biopsy specimens could be promising biomarkers for disease activity, symptom, and endoscopic response in Korea.
#Endoscopy #Eosinophilic esophagitis #Esophagus

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참고문헌 (31)

참고문헌 신청
Straumann A / 2008 / Eosinophilic esophagitis : analysis of food impaction and perforation in 251 adolescent and adult patients / Clin Gastroenterol Hepatol 6:598~600 google schola Ga Hee Kim / 2018 / Diagnostic Trends and Clinical Characteristics of Eosinophilic Esophagitis: A Korean, Single-center Database Study / Journal of Neurogastroenterology and Motility (JNM) 24(2):248~254 dbpia 이정호 / 2013 / Clinical Analysis of Primary Eosinophilic Esophagitis / Journal of Neurogastroenterology and Motility (JNM) 19(2):204~209 dbpia Liacouras CA / 2011 / Eosinophilic esophagitis : updated consensus recommendations for children and adults / J Allergy Clin Immunol 128:3~20 google schola Dellon ES / 2013 / ACG clinical guideline : evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis(EoE) / Am J Gastroenterol 108:679~692 google schola

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