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논문 기본 정보

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학술저널
저자정보
Jang Jae-Hyuk (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) Woo Seong-Dae (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) Lee Youngsoo (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) Kim Chang-Keun (Asthma and Allergy Center Department of Pediatrics Inje University Sanggye Paik Hospital Seoul Kore) 신유섭 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 예영민 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 박해심 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.2
발행연도
2021.1
수록면
330 - 338 (9page)

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Patients with severe eosinophilic asthma (SEA) suffer from frequent asthma exacerbations, where eosinophils are major effector cells in airway inflammation, and anti-interleukin (IL)-5 becomes an effective treatment modality to control eosinophilic inflammation of SEA. Fifteen patients with SEA who had been treated with anti-IL5 (reslizumab, 100 mg monthly intravenously) for 6 months at Ajou University Hospital (Suwon, Korea) were enrolled in this study. Clinical parameters, including total blood eosinophil count (TEC), FEV1%, fractional exhaled nitric oxide (FeNO) levels, and serum biomarkers such as eosinophil-derived neurotoxin (EDN), periostin (PON), and transforming growth factor-β1 (TGF-β1), were analyzed. EDN levels and TEC decreased significantly after 1 month of treatment (P < 0.05 for both), while no changes were noted in FeNO/PON/TGF-β1 levels. FEV1% increased after 2 months of treatment (P < 0.05). A positive correlation was observed between TEC and EDN levels (r = 0.60, P = 0.02). Significant negative correlations were noted between age and TEC/EDN levels (r = −0.57, P = 0.02 and r = −0.56, P = 0.03, respectively). Baseline TEC was higher in the EDN-responder group (≥75% decrease) than in the non-responder group (P = 0.06) with a positive correlation between %reduction in EDN and TEC (r = 0.67, P = 0.01). The onset age was younger and asthma duration was longer in the FEV1%-non-responder group (<12% increase) than in the FEV1%-responder group (P = 0.07 and P = 0.007, respectively). In conclusion, changes in the serum EDN level may be a potential biomarker for monitoring eosinophilic inflammation after anti-IL5 treatment in SEA, which is affected by onset age and asthma duration.
#Asthma #eosinophils #interleukin-5 #antibodies #monoclonal #inflammation #asthma exacerbation

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참고문헌 (35)

참고문헌 신청
Global Initiative for Asthma / Global strategy for asthma management and prevention google schola Gour N / 2015 / IL-4 and IL-13 signaling in allergic airway disease / Cytokine 75:68~78 google schola Wu AY / 2019 / Interleukin-4/interleukin-13 versus interleukin-5 : a comparison of molecular targets in biologic therapy for the treatment of severe asthma / Curr Opin Allergy Clin Immunol 19:30~37 google schola Johansson MW / 2013 / αMβ2 integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin / Am J Respir Cell Mol Biol 48:503~510 google schola Izuhara K / 2017 / Periostin in inflammation and allergy / Cell Mol Life Sci 74:4293~4303 google schola

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