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논문 기본 정보

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학술저널
저자정보
Kim Minjae (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Hwang Shin (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Song Gi-Won (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Ahn Chul-Soo (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Moon Deok-Bog (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Jung Dong-Hwan (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Park Gil-Chun (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent) Lee Sung-Gyu (Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Cent)
저널정보
대한이식학회 Clinical Transplantation and Research Korean Journal of Transplantation Vol.35 No.2
발행연도
2021.1
수록면
116 - 123 (8page)

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Salvage liver transplantation (LT) is a definite treatment for recurrent hepatocellular carcinoma (HCC) after hepatectomy. Combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CC) is not eligibly indicated for LT because of high post-transplant recurrence. We present a case of salvage living donor liver transplantation (LDLT) in a patient with tumor recurrence after surgical resection of cHCC-CC. A 61-year-old male patient diagnosed with chronic hepatitis B underwent right posterior sectionectomy for HCC. The pathological diagnosis revealed presence of a 3.2-cm-sized cHCC-CC with stem cell features and intermediate cell-subtype. Intrahepatic tumor recurrence occurred 9 months later and transarterial chemoembolization was performed. Due to the progress of recurrent tumors, ABO-incompatible LDLT was performed. The explant liver pathology revealed four small masses of cHCC-CC with stem cell features. Pulmonary metastasectomy and chest wall resection were performed for metastatic lesions at 10 months after LT. Multiple tumor recurrence was detected at 21 months after LT with progression despite sorafenib administration. Currently, the patient is alive for past 26 months after LT. In conclusion, the clinical sequences of this case suggest that the role of salvage LT for cHCC-CC is much more limited than that for HCC because the tumor biology of cHCC-CC is more aggressive compared with HCC.
#Hepatectomy #Tumor marker #Neoadjuvant therapy #Recurrence #Tumor biology

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참고문헌 (15)

참고문헌 신청
Jung DH / 2017 / Longterm prognosis of combined hepatocellular carcinoma-cholangiocarcinoma following liver transplantation and resection / Liver Transpl 23:330~341 google schola Sapisochin G / 2016 / Liver transplantation for"very early"intrahepatic cholangiocarcinoma : international retrospective study supporting a prospective assessment / Hepatology 64:1178~1188 google schola Jung DH / 2017 / Post-resection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma according to the 2010 WHO classification / World J Surg 41:1347~1357 google schola Lee JH / 2011 / Long-term prognosis of combined hepatocellular and cholangiocarcinoma after curative resection comparison with hepatocellular carcinoma and cholangiocarcinoma / J Clin Gastroenterol 45:69~75 google schola Garancini M / 2014 / Combined hepatocellular-cholangiocarcinoma : a population-level analysis of an uncommon primary liver tumor / Liver Transpl 20:952~959 google schola

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