지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.2
- 발행연도
- 2015.1
- 수록면
- 100 - 105 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Preformed circulating donor-specific antibodies (DSAs) immunologically challenge vascular endothelium and the bile duct. However, the liver is an immune-tolerant organ and can avoid immunological challenges. This study was undertaken to analyze the effects of DSAs after adult living donor liver transplantation (LDLT).
Methods: We retrospectively reviewed 219 LDLT patients’ records treated at our center.
Results: Of the 219 patients, 32 (14.6%) were DSA (+) and 187 (85.4%) were DSA (?). Class I DSAs were present in 18 patients, class II in seven patients, and both in seven patients. Seven patients (3.2%) showed DSA to HLA-A, four (1.8%) to HLA-B, seven (3.2%) to HLA-DR, and 14 (6.4%) to two or more HLAs. More DSAs were observed in female recipients than male recipients in the DSA (+) group. The DSA (+) group showed significantly higher levels of class I and II panel reactive antibody (PRA) than did the DSA (?) group. No significant intergroup differences were found between incidences of primary nonfunction, acute rejection, vascular complication, or biliary complication. There were no significant differences in graft survival rates between the two groups. However, the recipients with multiple DSAs tended to have more acute rejection episodes and events of biliary stricture and lower graft survival rates than did patients in the DSA (?) group.
Conclusion: In LDLT, the presence of multiple DSAs and high PRA seemed to be associated with poor graft outcomes, although our results did not reach statistical significance. Large cohort studies are necessary to clarify the impact of DSA and PRA in LDLT.
Methods: We retrospectively reviewed 219 LDLT patients’ records treated at our center.
Results: Of the 219 patients, 32 (14.6%) were DSA (+) and 187 (85.4%) were DSA (?). Class I DSAs were present in 18 patients, class II in seven patients, and both in seven patients. Seven patients (3.2%) showed DSA to HLA-A, four (1.8%) to HLA-B, seven (3.2%) to HLA-DR, and 14 (6.4%) to two or more HLAs. More DSAs were observed in female recipients than male recipients in the DSA (+) group. The DSA (+) group showed significantly higher levels of class I and II panel reactive antibody (PRA) than did the DSA (?) group. No significant intergroup differences were found between incidences of primary nonfunction, acute rejection, vascular complication, or biliary complication. There were no significant differences in graft survival rates between the two groups. However, the recipients with multiple DSAs tended to have more acute rejection episodes and events of biliary stricture and lower graft survival rates than did patients in the DSA (?) group.
Conclusion: In LDLT, the presence of multiple DSAs and high PRA seemed to be associated with poor graft outcomes, although our results did not reach statistical significance. Large cohort studies are necessary to clarify the impact of DSA and PRA in LDLT.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Hori T. / 2010 / Does a positive lymphocyte cross-match contraindicate livingdonor liver transplantation? / Surgery 147 : 840 ~ 844
2. [학술지(정기간행물)] - Suehiro T. / 2005 / Influence of HLA compatibility and lymphocyte cross-matching on acute cellular rejection following living donor adult liver transplantation / Liver Int 25 : 1182 ~ 1188
3. [학술지(정기간행물)] - Ratner LE. / 1991 / Immunology of renal allograft rejection / Arch Pathol Lab Med 115 : 283 ~ 287
4. [학술지(정기간행물)] - Abu-Elmagd KM. / 2012 / Preformed and de novo donor specific antibodies in visceral transplantation : long-term outcome with special reference to the liver / Am J Transplant 12 : 3047 ~ 3060
5. [학술지(정기간행물)] - Pons JA. / 2011 / Development of immune tolerance in liver transplantation / Gastroenterol Hepatol 34 : 155 ~ 169
2. [학술지(정기간행물)] - Suehiro T. / 2005 / Influence of HLA compatibility and lymphocyte cross-matching on acute cellular rejection following living donor adult liver transplantation / Liver Int 25 : 1182 ~ 1188
3. [학술지(정기간행물)] - Ratner LE. / 1991 / Immunology of renal allograft rejection / Arch Pathol Lab Med 115 : 283 ~ 287
4. [학술지(정기간행물)] - Abu-Elmagd KM. / 2012 / Preformed and de novo donor specific antibodies in visceral transplantation : long-term outcome with special reference to the liver / Am J Transplant 12 : 3047 ~ 3060
5. [학술지(정기간행물)] - Pons JA. / 2011 / Development of immune tolerance in liver transplantation / Gastroenterol Hepatol 34 : 155 ~ 169
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UCI(KEPA) : I410-ECN-0101-2016-514-001071665