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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 317 - 324 (8page)
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초록· 키워드
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Background: Recurrent glomerulonephritis (GN) is a common cause of allograft loss in kidney transplantation (KT), the most frequent of which is immunoglobulin A (IgA) nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays a major role in the pathophysiology of IgAN, but the association between Gd-IgA1 and recurrent IgAN in kidney transplant recipients (KTRs) is uncertain. We aimed to evaluate the efficacy of Gd-IgA1 for prediction of recurrent IgAN and graft and patient survival according to Gd-IgA1 level. Methods: We enrolled 27 KTRs who underwent allograft biopsy between 2009 and 2016 and measured the serum Gd-IgA1 level of each KTR. We divided the patients into two groups: nonrecurrent IgAN (patients with IgAN prior to KT who were not diagnosed with recurrent IgAN) and recurrent IgAN (patients with IgAN prior to KT who were diagnosed with recurrent IgAN). Results: The mean serum Gd-IgA1 level was significantly higher in the recurrent IgAN group than in the nonrecurrent IgAN group (6,419 ± 3,675 ng/mL vs. 3,381 ± 2,844 ng/mL, p = 0.02). The cutoff value of serum Gd-IgA1 in receiver operating characteristic curve analysis was 4,338 ng/mL (area under the curve, 0.76; 95% confidence interval [CI], 0.57–0.95, p = 0.02). Serum Gd-IgA1 level was an independent factor for recurrent IgAN (odds ratio, 17.60; 95% CI, 1.33–233.03, p = 0.03). There was no significant difference in graft or patient survival between the two groups. Conclusion: Serum Gd-IgA1 can be used as a diagnostic biomarker for recurrent IgAN in KT.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Wang AY / 2001 / Recurrent IgA nephropathy in renal transplant allografts / Am J Kidney Dis 38:588~596
Jung NamAn / 2012 / Incidenceofpost-transplantglomerulonephritisanditsimpact on graftoutcome / Kidney Research and Clinical Practice 31(4):219~226
Chang S / 2020 / The role of immune modulation in pathogenesis of IgA nephropathy / Front Med(Lausanne) 7:92
Jürgen Floege / 2013 / Primary glomerulonephritis: A review of important recent discoveries / Kidney Research and Clinical Practice 32(3):103~110
Hara S / 2015 / Banff 2013 update : pearls and pitfalls in transplant renal pathology / Nephrology (Carlton) 20(Suppl 2):2~8
Jung NamAn / 2012 / Incidenceofpost-transplantglomerulonephritisanditsimpact on graftoutcome / Kidney Research and Clinical Practice 31(4):219~226
Chang S / 2020 / The role of immune modulation in pathogenesis of IgA nephropathy / Front Med(Lausanne) 7:92
Jürgen Floege / 2013 / Primary glomerulonephritis: A review of important recent discoveries / Kidney Research and Clinical Practice 32(3):103~110
Hara S / 2015 / Banff 2013 update : pearls and pitfalls in transplant renal pathology / Nephrology (Carlton) 20(Suppl 2):2~8
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