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논문 기본 정보

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학술저널
저자정보
Ryohei Hayashi (Department of Endoscopy Hiroshima University Hospital) Yoshitaka Ueno (Department of Endoscopy Hiroshima University Hospital) Tanaka Shinji (Department of Endoscopy Hiroshima University Hospital Hiroshima Japan) Kana Onishi (Department of Gastroenterology and Metabolism Hiroshima University Hospital) Takeshi Takasago (Department of Gastroenterology and Metabolism Hiroshima University Hospital) Masaki Wakai (Department of Gastroenterology and Metabolism Hiroshima University Hospital) Toshikatsu Naito (Department of Gastroenterology and Metabolism Hiroshima University Hospital) Kensuke Sasaki (Department of Nephrology Hiroshima University Hospital) Shigehiro Doi (Department of Nephrology Hiroshima University Hospital) Takao Masaki (Department of Nephrology Hiroshima University Hospital) Chayama Kazuaki (Department of Gastroenterology and Metabolism Hiroshima University Hospital Hiroshima Japan)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.19 No.4
발행연도
2021.10
수록면
430 - 437 (8page)
DOI
10.5217/ir.2020.00067

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Background/Aims: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract. Some patients with this condition have been reported to present with immunoglobulin A nephropathy (IgAN), a renal complication that can cause end-stage renal failure, but the frequency of this comorbidity has not been described. Thus, the aim of this study was to investigate the frequency of IgAN in patients with IBD.Methods: This study included 620 patients with IBD (338 with ulcerative colitis [UC] and 282 with Crohn’s disease [CD]) from the Hiroshima University Hospital outpatient department. IgAN cases were identified from medical interviews, blood examinations (serum immunoglobulin A), and urinalyses (occult blood, proteinuria). Definitive IgAN cases were diagnosed by renal biopsies, while those detected through the clinical course and test results, but not clinically recommended for renal biopsy, were defined as suspected IgAN.Results: We analyzed 427 cases meeting the inclusion criteria (220 with UC and 207 with CD). The incidence of IgAN across all patients with IBD was 3.0%. The frequency of IgAN was significantly higher in patients with CD (11/207, 5.3%) than in those with UC (2/220, 0.9%) (P< 0.01). Moreover, a significant correlation was found between CD patients with ileostomy or colostomy and a diagnosis of IgAN.Conclusions: Patients with IBD present a high incidence of IgAN, especially those with CD who have undergone ileostomy or colostomy.

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