지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 334 - 343 (10page)
이용수
초록· 키워드
오류제보하기
Background: Ferric carboxymaltose (FCM) is a parenteral, dextran-free iron formulation designed to overcome the limitations of existing iron preparations. The main aim of this study was to retrospectively examine results obtained from a long period of FCM therapy in hemodialysis patients who have been previously treated with ferric gluconate (FX). Markers of iron metabolism, erythropoietin (EPO) doses, and effects on anemic status have been analysed. Methods: The study was performed with a follow up period of 4 years, when patients were treated before with FX and then switched to FCM. A total of 25 patients were included in the study. Results: FCM increased transferrin saturation (TSAT) levels by 11.9% (P < 0.001) with respect to FX. Events of TSAT less than 20% were reduced during FCM. The monthly dose of EPO was reduced in the FCM period (-6,404.1 international unit [IU]; 95% confidence interval, -10,643.5 IU; -2,164.6 IU; P = 0.003), as well as the erythropoietin resistance index (P = 0.004). During the period with FCM, ferritin levels were higher than during FX (P < 0.001), while transferrin was reduced (P = 0.001). Conclusion: During FCM treatment, minor doses of EPO were administered if compared to those delivered during FX therapy. Stable and on target levels of hemoglobin were maintained with better control of anemia through high levels of ferritin and TSAT.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Kidney Disease: Improving Global Outcomes (KDIGO)Anemia Work Group / 2012 / KDIGO clinical practice guideline for anemia in chronic kidney disease / Kidney Int Suppl 2:279~335
Eleftheriadis T / 2009 / The role of hepcidin in iron homeostasis and anemia in hemodialysis patients / Semin Dial 22:70~77
Lyseng-Williamson KA / 2009 / Ferric carboxymaltose : a review of its use in iron-deficiency anaemia / Drugs 69:739~756
Muñoz M / 2019 / Pharmacokinetics of ferric bepectate-a new intravenous iron drug for treating iron deficiency / Basic Clin Pharmacol Toxicol 125:133~141
Danielson BG / 2004 / Structure, chemistry, and pharmacokinetics of intravenous iron agents / J Am Soc Nephrol 15(Suppl 2):S93~S98
Eleftheriadis T / 2009 / The role of hepcidin in iron homeostasis and anemia in hemodialysis patients / Semin Dial 22:70~77
Lyseng-Williamson KA / 2009 / Ferric carboxymaltose : a review of its use in iron-deficiency anaemia / Drugs 69:739~756
Muñoz M / 2019 / Pharmacokinetics of ferric bepectate-a new intravenous iron drug for treating iron deficiency / Basic Clin Pharmacol Toxicol 125:133~141
Danielson BG / 2004 / Structure, chemistry, and pharmacokinetics of intravenous iron agents / J Am Soc Nephrol 15(Suppl 2):S93~S98
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