지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제21권 제2호
- 발행연도
- 2023.5
- 수록면
- 288 - 295 (8page)
- DOI
- 10.9758/cpn.2023.21.2.288
이용수
초록· 키워드
오류제보하기
Objective: Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder. Diagnosis of GAD depends on sub jective complaints of patients, thus the need for biological markers is constantly emerging. In this study, we aimed to the investigate diagnostic values of Erythropoietin (Epo) and its receptor (EpoR) levels in drug-naïve patients with GAD.
Methods: This study included 45 newly diagnosed drug-naive patients with GAD, aged and sex-matched 30 healthy controls. Medical histories were obtained, and physical examinations and laboratory tests were conducted. Also, the Hamilton Anxiety Rating Scale (HAM-A) was used for all participants. Serum Epo and EpoR levels were measured by ELISA.
Results: HAM-A score was significantly higher in GAD patients versus the controls (p ＜ 0.05). While the levels of Epo in patients with GAD were lower than the control patients, EpoR levels were increased in these patients (p ＜ 0.05). Epo/EpoR ratios were significantly lower in the patients with GAD than in the control subjects (p ＜ 0.05). A positive significant correlation was observed between the EpoR level and the HAM-A score (r = 0.755, p ＜ 0.001).
However, there was a negative significant correlation between Epo levels and HAM-A score (r = −0.749, p ＜ 0.001).
Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curves were 0.901 and 0.912, respectively.
Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in GAD patients.
Our results reveal possible diagnostic value of Epo and EpoR. Moreover, Epo therapy may be a good choice for GAD treatment.
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