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논문 기본 정보

자료유형
학술저널
저자정보
Se-Hoon Shim (Soonchunhyang University Cheonan Hospital) Yong-Ku Kim (Korea University) Young Hwangbo (Soonchunhyang University) Heejung Yoon (Korean Society of Infectious Diseases) Ji Sun Kim (Soonchunhyang University) Youn Jung Lee (Gyeongsang National University) Young Sup Woo (The Catholic University of Korea) Won-Myong Bahk (The Catholic University of Korea)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제2호
발행연도
2021.1
수록면
334 - 340 (7page)

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Objective: There are animal models associating dopamine dysfunction with behavioral impairments that model attention deficit hyperactivity disorder (ADHD). Erythropoietin (EPO) has trophic effects on dopaminergic neurons. The aim of this study was to examine the EPO plasma levels and determine whether there was any correlation between plasma EPO levels and clinical characteristics of ADHD. Methods: Plasma EPO levels were measured in 78 drug-naive children with ADHD and in 81 healthy children. The severity of ADHD symptoms was determined by scores on the Korean ADHD Rating Scale (K-ARS) in ADHD children and healthy controls. Results: The difference between median plasma EPO levels in ADHD children and in healthy controls was not statistically significant. Adjusting for age and sex, a linear regression analysis showed that inattention score was significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Hyperactivity-impulsivity score was significantly higher in the highest tertile of plasma EPO compared to those in the lowest tertile. Moreover, total K-ARS scores were significantly higher in the second highest tertile of plasma EPO compared to those in the lowest tertile. Conclusion: These findings suggest that plasma EPO levels were related to some ADHD symptoms, which could be used in the monitoring of the disorder.

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