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논문 기본 정보

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학술저널
저자정보
Sung-Hwan Kim (Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea) Sang Hong Baek (College of Medicine The Catholic University of Korea Seoul) Sung Cheol Yun (University of Ulsan College of Medicine Asan Medical Center) Jin Joo Park (Seoul National University Bundang Hospital Seongnam Korea) Sang Eun Lee (Asan Medical Center University of Ulsan College of Medicine) Eun-Seok Jeon (Sungkyunkwan University College of Medicine) Jae-Joong Kim (Asan Medical Center) Myeong-Chan Cho (Chungbuk National University College of Medicine) Shung Chull Chae (Kyungpook National University College of Medicine) Seok-Min Kang (Yonsei University College of Medicine) Dong-Ju Choi (Seoul National University Bundang Hospital) Byung-Su Yoo (Yonsei University Wonju College of Medicine) Kye Hun Kim (Heart Research Center of Chonnam National University) Byung-Hee Oh (Seoul National University Hospital Seoul)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.49 No.3
발행연도
2019.1
수록면
238 - 248 (11page)

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Background and Objectives: Beta-blockers are indicated in patients with heart failure (HF) with reduced ejection fraction. However, their efficacy in patients with HF with preserved ejection fraction (HFpEF) is uncertain. We investigated the hypothesis that beta-blockers are associated with reduced adverse events in patients with HFpEF. Methods: The Korea Acute Heart Failure (KorAHF) is a prospective observational multicentre cohort study. The 5,625 patients hospitalized for acute HF syndrome in 10 tertiary university hospitals across the country have been consecutively enrolled between March 2011 and February 2014. Of these patients, 2,152 patients with HFpEF (ejection fraction ≥40%) were investigated. The primary outcome was all-cause mortality according to beta-blocker use. Results: During a median follow-up duration of 807 days, 702 patients died. In Cox proportional hazards model beta-blocker use was associated with a 14% reduced all-cause death (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.75–0.98), but not with reduce rehospitalization (HR, 1.03; 95% CI, 0.85–1.27). In the propensity-score matched population, beta-blockers were also associated with reduced all-cause death (HR, 0.80; 95% CI, 0.69–0.94) but not with reduced rehospitalization (HR, 1.08; 95% CI, 0.87–1.33). Conclusions: In Korean patients with HFpEF, use of beta-blockers is associated with reduced all-cause death but not with reduced rehospitalization.
#Adrenergic beta-antagonist #Heart failure #Diastole

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참고문헌 (24)

참고문헌 신청
Steinberg BA / 2012 / Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction : prevalence, therapies, and outcomes / Circulation 126:65~75 google schola Borlaug BA / 2014 / The pathophysiology of heart failure with preserved ejection fraction / Nat Rev Cardiol 11:507~515 google schola Butler J / 2014 / Developing therapies for heart failure with preserved ejection fraction : current state and future directions / JACC Heart Fail 2:97~112 google schola Senni M / 2014 / New strategies for heart failure with preserved ejection fraction : the importance of targeted therapies for heart failure phenotypes / Eur Heart J 35:2797~2815 google schola Ponikowski P / 2016 / 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure : the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology(ESC)Developed with the special contribution of the Heart Failure Association(HFA)of the ESC / Eur Heart J 37:2129~2200 google schola

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