지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database. Methods: We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR). Results: Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker. Conclusions: Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Arrighi HM / 1991 / Natural history of benign prostatic hyperplasia and risk of prostatectomy. The Baltimore Longitudinal Study of Aging / Urology 38 : 4 ~ 8
Butt DA / 2012 / The risk of hip fracture after initiating antihypertensive drugs in the elderly / Arch Intern Med 172 : 1739 ~ 1744
Chrischilles E / 2001 / Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia:
Feldstein C / 2012 / Orthostatic hypotension: a common, serious and underrecognized problem in hospitalized patients / J Am Soc Hypertens 6 : 27 ~ 39
Lee YK / 2012 / Mortality after vertebral fracture in Korea : analysis of the National Claim Registry / Osteoporos Int 23 : 1859 ~ 1865
Butt DA / 2012 / The risk of hip fracture after initiating antihypertensive drugs in the elderly / Arch Intern Med 172 : 1739 ~ 1744
Chrischilles E / 2001 / Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia:
Feldstein C / 2012 / Orthostatic hypotension: a common, serious and underrecognized problem in hospitalized patients / J Am Soc Hypertens 6 : 27 ~ 39
Lee YK / 2012 / Mortality after vertebral fracture in Korea : analysis of the National Claim Registry / Osteoporos Int 23 : 1859 ~ 1865
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