지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism. (J Menopausal Med 2015;21:79-81)
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참고문헌 (15)
참고문헌 신청
Bologa CG. / 2006 / Virtual and biomolecular screening converge on a selective agonist for GPR30 / Nat Chem Biol 2 : 207 ~ 212
Filardo EJ. / 2000 / Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal
Filardo EJ. / 2005 / GPR30 : a seven-transmembranespanning estrogen receptor that triggers EGF release / Trends Endocrinol Metab 16 : 362 ~ 367
Heldring N. / 2007 / Estrogen receptors : how do they signal and what are their targets / Physiol Rev 87 : 905 ~ 931
Ji TH. / 1998 / G protein-coupled receptors. I. Diversity of receptor-ligand interactions / J Biol Chem 273 : 17299 ~ 17302
Filardo EJ. / 2000 / Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal
Filardo EJ. / 2005 / GPR30 : a seven-transmembranespanning estrogen receptor that triggers EGF release / Trends Endocrinol Metab 16 : 362 ~ 367
Heldring N. / 2007 / Estrogen receptors : how do they signal and what are their targets / Physiol Rev 87 : 905 ~ 931
Ji TH. / 1998 / G protein-coupled receptors. I. Diversity of receptor-ligand interactions / J Biol Chem 273 : 17299 ~ 17302
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