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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 697 - 701 (5page)
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초록· 키워드
오류제보하기
Background: Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated. Methods: This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group. Results: Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity. Conclusion: Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Lenders JW / 2005 / Phaeochromocytoma / Lancet 366:665~675
Pacak K / 2007 / Pheochromocytoma:recommendations for clinical practice from the First International Symposium. October 2005 / Nat Clin Pract Endocrinol Metab 3:92~102
Raber W / 2000 / Diagnostic efficacy of unconjugated plasma metanephrines for the detection of pheochromocytoma / Arch Intern Med 160:2957~2963
Young WF Jr / 2007 / Clinical practice : the incidentally discovered adrenal mass / N Engl J Med 356:601~610
Lenders JW / 2014 / Pheochromocytoma and paraganglioma : an Endocrine Society Clinical Practice Guideline / J Clin Endocrinol Metab 99:1915~1942
Pacak K / 2007 / Pheochromocytoma:recommendations for clinical practice from the First International Symposium. October 2005 / Nat Clin Pract Endocrinol Metab 3:92~102
Raber W / 2000 / Diagnostic efficacy of unconjugated plasma metanephrines for the detection of pheochromocytoma / Arch Intern Med 160:2957~2963
Young WF Jr / 2007 / Clinical practice : the incidentally discovered adrenal mass / N Engl J Med 356:601~610
Lenders JW / 2014 / Pheochromocytoma and paraganglioma : an Endocrine Society Clinical Practice Guideline / J Clin Endocrinol Metab 99:1915~1942
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