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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 140 - 149 (10page)
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초록· 키워드
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Background: Although previous studies have demonstrated that irisin plays an anti-inflammatory role in the body, conflicting results have been reported regarding the correlation between serum levels of irisin and C-reactive protein (CRP). The present metaanalysis was conducted to further investigate the correlation between irisin and CRP levels. Methods: We systematically searched PubMed, the Cochrane Library, Web of Science, Embase, SCOPUS, and Ovid to retrieve studies assessing the correlation between irisin and CRP levels. Meta-analyses were performed using a random-effects model, and the I2 index was used to evaluate heterogeneity. Results: Of the 428 studies that were initially found, 14 studies with 2,530 participants met the inclusion criteria for the meta-analysis. The pooled effect size was calculated as 0.052 (95% confidence interval, −0.047 to 0.152; P=0.302). Subgroup analyses identified s ignificant, positive, but weak correlations between CRP and irisin levels in cohort studies, studies conducted among healthy participants, studies in which the male-to-female ratio was less than 1, in overweight or obese subjects, and in studies with a samplesize of at least 100 participants. Conclusion: The present meta-analysis found no overall significant correlation between irisin and CRP levels, although a significant positive correlation was found in overweight or obese subjects. Well-designed studies are needed to verify the results of the present meta-analysis.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Bostrom P / 2012 / A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Nature 481:463~468
Chen JQ / 2015 / Irisin : a new molecular marker and target in metabolic disorder / Lipids Health Dis 14:2
Mazur-Bialy AI / 2017 / Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/MyD88 signaling pathway activation / Int J Mol Sci 18:E701
Raschke S / 2013 / Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells / PLoS One 8:e62008
Xiang L / 2014 / Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy / Atherosclerosis 235:328~333
Chen JQ / 2015 / Irisin : a new molecular marker and target in metabolic disorder / Lipids Health Dis 14:2
Mazur-Bialy AI / 2017 / Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/MyD88 signaling pathway activation / Int J Mol Sci 18:E701
Raschke S / 2013 / Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells / PLoS One 8:e62008
Xiang L / 2014 / Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy / Atherosclerosis 235:328~333
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