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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis. Methods: The study included 88 women with postmenopausal osteoporosis. Based on World Health Organization criteria, women with a T-score of ≤ –2.5 were defined as osteoporotic. In this case-control study, postmenopausal women with T-score > –1 were selected as controls (n = 88) and case-matched in a 1:1 ratio based on age (within 2 years) and body mass index (BMI) (within 1.0 kg/m2). ApoM, irisin and chemerin levels were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) kit.Results: There were no significant differences in age, BMI, parity, cholesterol and apoM levels between the two groups. C-reactive protein levels were significantly increased in women with osteoporosis. Serum chemerin levels (240.1 ± 46.1 vs. 261.5 ± 50.8 ng/mL) were significantly lower in the women with osteoporosis, as compared to the controls (P = 0.004). Serum irisin levels were also decreased in women with osteoporosis (0.7 ± 0.2 vs. 0.8 ± 0.2 ng/mL; P = 0.007). Conclusions: In the present study, osteoporosis was associated with decreased levels of circulating chemerin and irisin. These findings suggested that adipokines might play a role in the pathogenesis of osteoporosis. (J Menopausal Med 2016;22:76-79)
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참고문헌 (13)
참고문헌 신청
Upadhyay J / 2015 / The role of leptin in regulating bone metabolism / Metabolism 64:105~113
Scotece M / 2014 / Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery? / Expert Opin Drug Discov 9:945~957
Biver E / 2011 / Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis / J Clin Endocrinol Metab 96:2703~2713
Tsuji K / 2010 / Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3synthesis in leptin-deficient mice / J Bone Miner Res 25:1711~1723
Arias-Loste MT / 2014 / Irisin, a link among fatty liver disease, physical inactivity and insulin resistance / Int J Mol Sci 15:23163~23178
Scotece M / 2014 / Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery? / Expert Opin Drug Discov 9:945~957
Biver E / 2011 / Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis / J Clin Endocrinol Metab 96:2703~2713
Tsuji K / 2010 / Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3synthesis in leptin-deficient mice / J Bone Miner Res 25:1711~1723
Arias-Loste MT / 2014 / Irisin, a link among fatty liver disease, physical inactivity and insulin resistance / Int J Mol Sci 15:23163~23178
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