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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 89 - 94 (6page)
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초록· 키워드
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The dose-dependent effect of progesterone on PI3K/AKT signaling pathway, which plays a vital role in regulating various biological processes in human breast cancer, is not well defined. Herein, we analyzed the dose-associated influence of progesterone on AKT activation in human breast cancer cells. MCF-7 cells were treated with progesterone at a concentration ranging from 10<SUP>-10</SUP> M through 10<SUP>-6</SUP> M for 30 minutes and the extent of AKT phosphorylation was assessed using western blotting. Treatment with progesterone at various concentrations led to AKT phosphorylation in these cells. Notably, AKT activation, when treated with lower doses of progesterone was higher than that observed upon treatment with higher doses. Pre-treatment with PI3K inhibitor (LY294002) attenuated progesterone-induced AKT activation in a parallel manner over the range of progesterone doses administered. RU486, which is a progesterone receptor antagonist, induced AKT phosphorylation. These results suggest that progesterone seems to induce dose-dependent differential activation of PI3K/AKT pathway in MCF-7 cells.
목차
ABSTRACT
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
References
참고문헌 (32)
참고문헌 신청
Druckmann R / 2003 / Progestins and their effects on the breast / Maturitas 4646S1:59~69
Kurebayashi J / 2005 / Resistance to endocrine therapy in breast cancer / Cancer Chemother Pharmacol 56(1):39~46
Trabert B / 2020 / Progesterone and breast cancer / Endocr Rev 41:320~344
Trayes KP / 2021 / Breast cancer treatment / Am Fam Physician 104:171~178
Seeger H / 2003 / Comparison of the effect of progesterone, medroxyprogesterone acetate and norethisterone on the proliferation of human breast cancer cells / J Br Menopause Soc 9:36~38
Kurebayashi J / 2005 / Resistance to endocrine therapy in breast cancer / Cancer Chemother Pharmacol 56(1):39~46
Trabert B / 2020 / Progesterone and breast cancer / Endocr Rev 41:320~344
Trayes KP / 2021 / Breast cancer treatment / Am Fam Physician 104:171~178
Seeger H / 2003 / Comparison of the effect of progesterone, medroxyprogesterone acetate and norethisterone on the proliferation of human breast cancer cells / J Br Menopause Soc 9:36~38
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UCI(KEPA) : I410-ECN-0101-2022-047-000055646