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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,195 - 1,206 (12page)
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Background B cell lymphoma (BCL) families play an important role in apoptosis as a growth factor, cell death programming, cytokine expression and immune-related genes expression. Objectives In this study, to investigate the roles of BCLs, we performed genome-wide identification, expression and functional analyses of the BCL family in chicken. Methods Chicken BCLs genes were identified and analyzed by using bioinformatics approach. Expression profiles and Hierarchical cluster analysis of the BCLs genes in different chicken tissues were obtained from the genome-wide RNA-seq in the GEO, and Cluster and Java Treeview, respectively. Results A total of 16 BCLs genes were identified from the chicken genome, which could be further classified into five distinct groups in the phylogenetic tree. On the other hand, the interaction among BCLs proteins and between BCLs proteins with NF-κB subunits are limited, indicating that the remaining the functions of BCLs protein could be investigated in chicken. Moreover, KEGG pathway analysis indicated that BCL gene family was involved in regulation of apoptotic and immune response. Finally, BCL gene family was differentially expressed in chicken tissues, pathogen infection and growth stages of early chicken early embryo. Conclusion This study provides significant insights into the potential functions of BCLs in chicken, including the regulation of apoptosis, cell death and expression of immune-related genes.
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참고문헌 (61)
참고문헌 신청
Alinikula J / 2011 / Alternate pathways for BCL6-mediated regulation of B cell to plasma cell differentiation / Eur J Immunol 41:2404~2413
Amen F / 2007 / Absence of cyclin-D2and BCL-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients / Histopathology 51:70~79
Artimo P / 2012 / ExPASy: SIB bioinformatics resource portal / Nucleic Acids Res 40:W597~W603
Bailey TL / 2009 / MEME SUITE: tools for motif discovery and searching / Nucleic Acids Res 37:W202~W208
Sumit Bhattacharyya / 2009 / B-cell CLL/Lymphoma 10 (BCL10) Is Required for NF-κB Production by Both Canonical and Noncanonical Pathways and for NF-κB-inducing Kinase (NIK) Phosphorylation / Journal of Biological Chemistry 285(1):522~530
Amen F / 2007 / Absence of cyclin-D2and BCL-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients / Histopathology 51:70~79
Artimo P / 2012 / ExPASy: SIB bioinformatics resource portal / Nucleic Acids Res 40:W597~W603
Bailey TL / 2009 / MEME SUITE: tools for motif discovery and searching / Nucleic Acids Res 37:W202~W208
Sumit Bhattacharyya / 2009 / B-cell CLL/Lymphoma 10 (BCL10) Is Required for NF-κB Production by Both Canonical and Noncanonical Pathways and for NF-κB-inducing Kinase (NIK) Phosphorylation / Journal of Biological Chemistry 285(1):522~530
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