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Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
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Type
Academic journal
Author
Lee-Han Kim (Yonsei University College of Medicine) Sung Jae Shin (Yonsei University College of Medicine)
Journal
The Korean Society For Microblology JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.46 No.4 KCI Accredited Journals SCOPUS
Published
2016.12
Pages
312 - 318 (7page)

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Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
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Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.
#Mycobacterium tuberculosis #Apoptosis #Bcl-2 family proteins #Anti-apoptotic proteins #Pro-apoptotic proteins

Contents

INTRODUCTION
CONCLUSION
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UCI(KEPA) : I410-ECN-0101-2017-475-002003598