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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 283 - 288 (6page)
- DOI
- 10.48022/mbl.2102.02009
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초록· 키워드
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This study investigated the anticancer activity of methanol extract from Platycarya strobilacea leaf in AGS human gastric cancer cells. We determined the cell viability effect of P. strobilacea using MTS assay. Apoptosis induction and cell cycle arrest were confirmed by fluorescein isothiocyanate and propidium iodide staining using cellometer K2. The mRNA expression levels of the Bcl-2 family were confirmed by reverse transcription-polymerase chain reaction. The cell viability was decreased in a dose-dependent manner treated with different concentrations of P. strobilacea. Total, early, and late apoptotic cells were dramatically increased, and the cell cycle was arrested at the sub-G1 phase. The mRNA expressions of Bcl-2 and Bcl-xL were reduced, whereas pro-apoptotic factors, Bax and Bak, were increased in a dose-dependent manner. These results suggested that P. strobilacea leaf extract induced significant apoptotic activity through an intrinsic mitochondria pathway.
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참고문헌 (26)
참고문헌 신청
Song M / 1987 / Efficaey of progressive muscle relaxation training in reducing nausea and vomiting, anxiety and symptom distress of cancer chemotherapy / J. Nurs. Acad. Soc 17:195~203
신성아 / 2016 / Piperine에 의한 위암세포 AGS 증식 억제와 Apoptosis 유도 / 한국식품영양과학회지 45(11):1589~1594
김은지 / 2008 / 목향 헥산추출물이 대장암세포인 HT-29 세포의 증식에 미치는 영향 / 한국식품과학회지 40(2):207~214
Hsu HF / 2008 / Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells / Food Chem. Toxicol 46:3785~3791
김경민 / 2009 / Characterization of a 27 kDa Fibrinolytic Enzyme from Bacillus amyloliquefaciens CH51 Isolated from Cheonggukjang / Journal of Microbiology and Biotechnology 19(9):997~1004
신성아 / 2016 / Piperine에 의한 위암세포 AGS 증식 억제와 Apoptosis 유도 / 한국식품영양과학회지 45(11):1589~1594
김은지 / 2008 / 목향 헥산추출물이 대장암세포인 HT-29 세포의 증식에 미치는 영향 / 한국식품과학회지 40(2):207~214
Hsu HF / 2008 / Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells / Food Chem. Toxicol 46:3785~3791
김경민 / 2009 / Characterization of a 27 kDa Fibrinolytic Enzyme from Bacillus amyloliquefaciens CH51 Isolated from Cheonggukjang / Journal of Microbiology and Biotechnology 19(9):997~1004
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