메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Gil-Chun Park (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Shin Hwang (Asan Medical Center) 김명수 (연세대학교) Dong-Hwan Jung (Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Gi Won Song (Asan Medical Center University of Ulsan College of Medicine) Kwang-Woong Lee (Department of Surgery Seoul National University College of Medicine Seoul Korea) Jong Man Kim (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine) Jae Geun Lee (Department of Surgery Yonsei niversity College of Medicine Seoul) Je Ho Ryu (Department of Surgery Pusan National University Yangsan Hospital) Dong Lak Choi (Catholic University of Daegu) Hee-Jung Wang (Ajou University School of Medicine Suwon Korea) Bong Wan Kim (Ajou University) Dong-Sik Kim (Department of Surgery Korea University College of Medicine Seoul Korea) Yang Won Nah (University of Ulsan College of Medicine) Young Kyoung You (Department of Surgery College of Medicine The Catholic University of Korea) Koo Jeong Kang (Keimyung University Dongsan Medical Center Keimyung University School of Medicine Daegu Korea) Hee Chul Yu (Chonbuk National University Hospital) 박요한 (인제대학교) 이경진 (University of Ulsan) Yun Kyu Kim (University of Ulsan College of Medicine)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.6
발행연도
2020.1
수록면
1 - 13 (13page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Prophylaxis for hepatitis B virus (HBV) recurrence is essential after liver transplantation (LT) in HBV-associated recipients. We conducted real-world analysis of HBV prophylaxis after LT in the Korean population. Methods: Korean Organ Transplantation Registry (KOTRY) database and additionally collected data (n = 326) were analyzed with special reference to types of HBV prophylaxis. Results: The study cohort comprised 267 cases of living-donor LT and 59 cases of deceased-donor LT. Hepatocellular carcinoma (HCC) was diagnosed in 232 (71.2%) of these subjects. Antiviral agents were used in 255 patients (78.2%) prior to LT. HBV DNA was undetectable in 69 cases (21.2%) and detectable over wide concentrations in the other 257 patients (78.8%) prior to LT. Polymerase chain reaction analysis of the store blood samples detected HBV DNA in all patients, with 159 patients (48.9%) showing concentrations > 100 IU/mL. Post-transplant HBV regimens during the first year included combination therapy in 196 (60.1%), hepatitis B immunoglobulin (HBIG) monotherapy in 121 (37.1%), and antiviral monotherapy in 9 (2.8%). In the second post-transplant year, these regimens had changed to combination therapy in 187 (57.4%), HBIG monotherapy in 112 (34.4%), and antiviral monotherapy in 27 (8.3%). Trough antibody to hepatitis B surface antigen titers > 500 IU/mL and >1,000 IU/mL were observed in 61.7% and 25.2%, respectively. The mean simulative half-life of HBIG was 21.6 ± 4.3 days with a median 17.7 days. Up to 2-year follow-up period, HCC recurrence and HBV recurrence developed in 18 (5.5%) and 6 (1.8%), respectively. HCC recurrence developed in 3 of 6 patients with HBV recurrence. Conclusion: Combination therapy is the mainstay of HBV prophylaxis protocols in a majority of Korean LT centers, but HBIG was often administered excessively. Individualized optimization of HBIG treatments using SHL is necessary to adjust the HBIG infusion interval.
#Hepatitis B Virus #Recurrence #Liver Transplantation #Hepatitis B Immunoglobulin #Antiviral Agent

목차

등록된 정보가 없습니다.

참고문헌 (16)

참고문헌 신청
Hwang S / 2008 / Prevention of hepatitis B recurrence after living donor liver transplantation : primary high-dose hepatitis B immunoglobulin monotherapy and rescue antiviral therapy / Liver Transpl 14(6):770~778 google schola Mohanty SR / 2005 / Management of hepatitis B in liver transplant patients / J Clin Gastroenterol 39(1):58~63 google schola Terrault N / 2005 / Management of the hepatitis B virus in the liver transplantation setting : a European and an American perspective / Liver Transpl 11(7):716~732 google schola Roche B / 2004 / Evolving strategies to prevent HBV recurrence / Liver Transpl 10(10 Suppl 2):S74~S85 google schola Ghany MG / 1998 / Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis / Hepatology 27(1):213~222 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0