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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,577 - 1,583 (7page)
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Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is universal and progressive. Here, we report recent results of response-guided therapy for HCV recurrence based on early protocol biopsy after LT. We reviewed patients who underwent LT for HCV related liver disease between 2010 and 2012. Protocol biopsies were performed at 3, 6, and 12 months after LT in HCV recurrence (positive HCV-RNA). For any degree of fibrosis, ≥ moderate inflammation on histology or HCV hepatitis accompanying with abnormal liver function, we treated with pegylated interferon and ribavirin. We adjusted treatment period according to individual response to treatment. Among 41 HCV related recipients, 25 (61.0%) who underwent protocol biopsies more than once were enrolled in this study. The mean follow-up time was 43.1 (range, 23-55) months after LT. Genotype 1 and 2 showed in 56.0% and 36.0% patients, respectively. Of the 25 patients, 20 (80.0%) started HCV treatment after LT. Rapid or early virological response was observed in 20 (100%) patients. Fifteen (75.0%) patients finished the treatment with end-of-treatment response. Sustained virological response (SVR) was in 11 (55.0%) patients, including 5 (41.7%) of 12 genotype 1 and 6 (75.0%) of 8 non-genotype 1 (P = 0.197). Only rapid or complete early virological response was a significant predictor for HCV treatment response after LT (100% in SVR group vs. 55.6% in non-SVR group, P = 0.026). Overall 3-yr survival rate was 100%. In conclusion, response-guided therapy for HCV recurrence based on early protocol biopsy after LT shows encouraging results.
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참고문헌 (40)
참고문헌 신청
Gane EJ / 1996 / Long-term outcome of hepatitis C infection after liver transplantation / N Engl J Med 334:815~820
Agarwal K / 2013 / Treatment of chronic hepatitis C virus infection after liver transplantation / Dig Liver Dis 45:S349~S354
Lange CM / 2013 / The importance of IL28B genotype in hepatitis C virus-associated liver transplantation / Liver Int 33:169~171
Rubin A / 2011 / Liver transplantation and hepatitis C / Clin Res Hepatol Gastroenterol 35:805~812
Gane EJ / 2014 / Directly acting antivirals(DAAs)for the treatment of chronic hepatitis C virus infection in liver transplant patients : "a flood of opportunity" / Am J Transplant 14:994~1002
Agarwal K / 2013 / Treatment of chronic hepatitis C virus infection after liver transplantation / Dig Liver Dis 45:S349~S354
Lange CM / 2013 / The importance of IL28B genotype in hepatitis C virus-associated liver transplantation / Liver Int 33:169~171
Rubin A / 2011 / Liver transplantation and hepatitis C / Clin Res Hepatol Gastroenterol 35:805~812
Gane EJ / 2014 / Directly acting antivirals(DAAs)for the treatment of chronic hepatitis C virus infection in liver transplant patients : "a flood of opportunity" / Am J Transplant 14:994~1002
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