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- 학술저널
- 저자정보
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- 2019.1
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Background: Tetrabromobisphenol A (TBBPA), one of the most widely used brominated flame-retardants, is a representative persistent organic pollutants group. Studies on TBBPA toxicity have been conducted using various target cells; however, few studies have investigated TBBPA toxicity in bone cells. Therefore, this study investigated the in vitro effects of TBBPA on osteoclasts, a cell type involved in bone metabolism. Methods: RAW264.7 cells were cultured in medium containing 50 ng/mL receptor activator of nuclear factor kappa B ligand (RANKL) and varying concentrations of TBBPA. To evaluate the effects of TBBPA on the differentiation and function of osteoclasts, osteoclast-specific gene expression, tartrate-resistant acid phosphatase (TRAP) activity, bone resorbing activity, mitochondrial membrane potential (MMP) and mitochondrial superoxide were measured. Results: The presence of 20 μM TBBPA significantly increased TRAP activity in RANKL- stimulated RAW264.7 cells, the bone resorbing activity of osteoclasts, and the gene expression of Akt2, nuclear factor of activated T-cells cytoplasmic 1, and chloride channel voltage-sensitive 7. However, TBBPA treatment caused no change in the expression of carbonic anhydrase II, cathepsin K, osteopetrosis-associated transmembrane protein 1, Src, extracellular signal-related kinase, GAB2, c-Fos, or matrix metalloproteinase 9. Furthermore, 20 μM TBBPA caused a significant decrease in MMP and a significant increase in mitochondrial superoxide production. Conclusion: This study suggests that TBBPA promotes osteoclast differentiation and activity. The mechanism of TBBPA-stimulated osteoclastogenesis might include increased expression of several genes involved in osteoclast differentiation and reactive oxygen species production.
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참고문헌 (44)
참고문헌 신청
Jarosiewicz M / 2017 / Tetrabromobisphenol A-toxicity, environmental and occupational exposures / Med Pr 68(1):121~134
Liu A / 2018 / Transformation/degradation of tetrabromobisphenol A and its derivatives: a review of the metabolism and metabolites / Environ Pollut 243(Pt B):1141~1153
McAvoy DC / 2016 / Biotransformation of tetrabromobisphenol A(TBBPA)in anaerobic digester sludge, soils, and freshwater sediments / Ecotoxicol Environ Saf 131:143~150
Peterman PH / 2000 / Detection of tetrabromobisphenol A and formation of brominated 13C-bisphenol A's in commercial drinking water stored in reusable polycarbonate containers / 219th ACS National Meeting :431
Johnson-Restrepo B / 2008 / Tetrabromobisphenol A(TBBPA)and hexabromocyclododecanes(HBCDs)in tissues of humans, dolphins, and sharks from the United States / Chemosphere 70(11):1935~1944
Liu A / 2018 / Transformation/degradation of tetrabromobisphenol A and its derivatives: a review of the metabolism and metabolites / Environ Pollut 243(Pt B):1141~1153
McAvoy DC / 2016 / Biotransformation of tetrabromobisphenol A(TBBPA)in anaerobic digester sludge, soils, and freshwater sediments / Ecotoxicol Environ Saf 131:143~150
Peterman PH / 2000 / Detection of tetrabromobisphenol A and formation of brominated 13C-bisphenol A's in commercial drinking water stored in reusable polycarbonate containers / 219th ACS National Meeting :431
Johnson-Restrepo B / 2008 / Tetrabromobisphenol A(TBBPA)and hexabromocyclododecanes(HBCDs)in tissues of humans, dolphins, and sharks from the United States / Chemosphere 70(11):1935~1944
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