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논문 기본 정보

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학술저널
저자정보
예영민 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 윤지원 (아주대학교) Woo Seong-Dae (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) Jang Jae-Hyuk (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) Lee Youngsoo (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 이현영 ((학)아주대학교의료원) 신유섭 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 남동호 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 박해심 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.3
발행연도
2021.1
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390 - 403 (14page)

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Purpose Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores during the initial 3 months of treatment in an attempt to investigate time to remission and relapse rates for CU and to identify predictors for CU remission. Methods In total, 4,552 patients (57.9% female; mean age of 38.6 years) with CU were included in this retrospective cohort study. The K-medoids algorithm was used for clustering CU patients. Kaplan-Meier survival analysis with Cox regression was applied to identify predictors of CU remission. Results Four distinct clusters were identified: patients with consistently low disease activity (cluster 1, n = 1,786), with medium-to-low disease activity (cluster 2, n = 1,031), with consistently medium disease activity (cluster 3, n = 1,332), or with consistently high disease activity (cluster 4, n = 403). Mean age, treatment duration, peripheral neutrophil counts, total immunoglobulin E, and complements levels were significantly higher for cluster 4 than the other 3 clusters. Median times to remission were also different among the 4 clusters (2.1 vs. 3.3 vs. 6.4 vs. 9.4 years, respectively, P < 0.001). Sensitization to house dust mites (HDMs; at least class 3) and female sex were identified as significant predictors of CU remission. Around 20% of patients who achieved CU remission experienced relapse. Conclusions In this study, we identified 4 CU patient clusters by analyzing medication scores during the first 3 months of treatment and found that sensitization to HDMs and female sex can affect CU prognosis. The use of immunomodulators was implicated in the risk for CU relapse.
#Chronic urticaria #cluster analysis #recurrence #database #cohort studies #survival analysis #prognosis #house dust mites

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참고문헌 (50)

참고문헌 신청
Zuberbier T / 2018 / The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria / Allergy 73:1393~1414 google schola 송우정 / 2020 / The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management / Allergy, Asthma & Immunology Research 12(4):563~578 dbpia Fricke J / 2020 / Prevalence of chronic urticaria in children and adults across the globe : systematic review with meta-analysis / Allergy 75:423~432 google schola Maurer M / 2011 / Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report / Allergy 66:317~330 google schola Gaig P / 2004 / Epidemiology of urticaria in Spain / J Investig Allergol Clin Immunol 14:214~220 google schola

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