지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,907 - 1,913 (7page)
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초록· 키워드
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Remission is a primary end point of in clinical practice and trials of treatments for rheumatoid arthritis (RA). The 2011 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria were developed to provide a consensus definition of remission. This study aimed to assess the concordance between the new remission criteria and the physician’s clinical judgment of remission and also to identify factors that affect the discordance between these two approaches. A total of 3,209 patients with RA were included from the KORean Observational Study Network for Arthritis (KORONA) database. The frequency of remission was evaluated based on each approach. The agreement between the results was estimated by Cohen’s kappa (κ). Patients with remission according to the 2011 ACR/EULAR criteria (i.e. the Boolean criteria) and/or physician judgment (n = 855) were divided into three groups: concordant remission, the Boolean criteria only, and physician judgment only. Multinomial logistic regression analysis was used to identify factors responsible for the assignment of patients with remission to one of the discordant groups rather than the concordant group. The remission rates using the Boolean criteria and physician judgment were 10.5% and 19.9%, respectively. The agreement between two approaches for remission was low (κ = 0.226) and the concordant remission rate was only 5.5% (n = 177). Pain affected classification in both discordant groups, whereas fatigue was associated with remission only by physician clinical judgment. The Boolean criteria were more stringent than clinical judgment. Patient subjective symptoms such as pain and fatigue were associated with discordance between the two approaches.
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참고문헌 (20)
참고문헌 신청
Kapetanovic MC / 2015 / Development of functional impairment and disability in rheumatoid arthritis patients followed for 20 years: relation to disease activity, joint damage, and comorbidity / Arthritis Care Res (Hoboken) 67:340~348
van Nies JA / 2014 / What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review / Ann Rheum Dis 73:861~870
Smolen JS / 2010 / Treating rheumatoid arthritis to target : recommendations of an international task force / Ann Rheum Dis 69:631~637
Singh JA / 2016 / 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis / Arthritis Rheumatol 68:1~26
Smolen JS / 2014 / EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update / Ann Rheum Dis 73:492~509
van Nies JA / 2014 / What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review / Ann Rheum Dis 73:861~870
Smolen JS / 2010 / Treating rheumatoid arthritis to target : recommendations of an international task force / Ann Rheum Dis 69:631~637
Singh JA / 2016 / 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis / Arthritis Rheumatol 68:1~26
Smolen JS / 2014 / EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update / Ann Rheum Dis 73:492~509
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