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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 150 - 157 (8page)
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초록· 키워드
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Background/Aims: Overlap syndrome of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) (AIH-PBC overlap syndrome) is a rare disease that has not been clearly characterized in Korean patients. This study investigated the clinical features of AIH-PBC overlap syndrome compared with those of AIH and PBC alone.
Methods: This retrospective cohort study included 158 consecutive patients who were diagnosed as AIH (n=61), PBC (n=81), or AIH-PBC overlap syndrome (n=9) based on the Paris and the International Autoimmune Hepatitis Group (IAIHG) criteria from 2001 to 2011 in Korea. We compared the clinical features of these three groups retrospectively, including their biochemical characteristics, treatments, responses, and clinical outcomes.
Results: The AIH-PBC overlap syndrome patients exhibited biochemical characteristics of both AIH and PBC, and showed a similar response to ursodeoxycholic acid (UDCA) monotherapy as for the PBC patients. However, the response of AIH-PBC overlap syndrome patients to UDCA and steroid combination therapy was worse than the response of AIH patients to steroid-based therapy (P=0.024). Liver cirrhosis developed more rapidly in AIH-PBC overlap syndrome patients than in AIH patients group (P=0.013), but there was no difference between AIH-PBC overlap syndrome patients and PBC patients. The rates of developing hepatic decompensation did not differ significantly between the groups.
Conclusions: The AIH-PBC overlap syndrome patients exhibited a worse response to UDCA and steroid combination therapy and a faster cirrhotic progression compared with AIH patients. (Clin Mol Hepatol 2015;21:150-157)
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참고문헌 (22)
참고문헌 신청
Alvarez F / 1999 / International Autoimmune Hepatitis Group Report : review of criteria for diagnosis of autoimmune hepatitis / J Hepatol 31 : 929 ~ 938
Boberg KM / 2011 / Overlap syndromes : the International Autoimmune Hepatitis Group(IAIHG)position statement on a controversial issue / J Hepatol 54 : 374 ~ 385
Chazouilleres O / 1998 / Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome : clinical features and response to therapy / Hepatology 28 : 296 ~ 301
Chazouilleres O / 2006 / Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome / J Hepatol 44 : 400 ~ 406
Corpechot C / 2008 / Biochemical response to ursodeoxycholic acid and long?term prognosis in primary biliary cirrhosis / Hepatology 48 : 871 ~ 877
Boberg KM / 2011 / Overlap syndromes : the International Autoimmune Hepatitis Group(IAIHG)position statement on a controversial issue / J Hepatol 54 : 374 ~ 385
Chazouilleres O / 1998 / Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome : clinical features and response to therapy / Hepatology 28 : 296 ~ 301
Chazouilleres O / 2006 / Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome / J Hepatol 44 : 400 ~ 406
Corpechot C / 2008 / Biochemical response to ursodeoxycholic acid and long?term prognosis in primary biliary cirrhosis / Hepatology 48 : 871 ~ 877
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