지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 291 - 298 (8page)
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초록· 키워드
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Background: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by specific autoantibodies. We evaluated the prevalence of autoantibodies against nucleoporin p62 (anti-p62) in PBC patients’ sera to determine whether it can be a marker for PBC, in comparison with other immunological and biochemical parameters. We validated the performance of our in-house ELISA technique. Methods: Serum samples were collected from 135 PBC patients. Thirty patients with primary sclerosing cholangitis (PSC) and 30 with autoimmune hepatitis (AIH) were included as pathological controls, and 40 healthy blood donors served as healthy controls. The presence of anti-p62 was determined by an in-house ELISA using a recombinant protein. We calculated the sensitivity, specificity, positive and negative predictive values (PPV and NPV), and positive and negative likelihood ratio (LR+ and LR-) of our in-house ELISA for diagnosing PBC based on anti-p62. Findings were correlated with biochemical data and survival. Results: Anti-p62 was detected in 32 PBC patients (23.7%). Specificity and PPV of anti-p62 for PBC were 99% and 97%, respectively. The difference between proportions of anti-p62-positive patients and controls was 0.23 (95% confidence interval [CI]: 0.03–0.40; P<0.0001); LR+ and LR- were 23.7 and 0.77, respectively. The presence of anti-p62 was associated with higher levels of bilirubin and alkaline phosphatase (P<0.001). The odds ratio for survival was 2.44 (95% CI: 0.87–6.87; P=0.091). Conclusions: Anti-p62 may be regarded as a significant serological marker of PBC.
목차
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참고문헌 (35)
참고문헌 신청
Carey EJ / 2015 / Primary biliary cirrhosis / Lancet 386:1565~1575
Invernizzi P / 2017 / Primary Biliary Cholangitis : advances in management and treatment of the disease / Dig Liver Dis 49:841~846
Kim KA / 2016 / Population-based epidemiology of primary biliary cirrhosis in South Korea / Aliment Pharmacol Ther 43:154~162
Boonstra K / 2012 / Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis : a systematic review / J Hepatol 56:1181~1188
Benedetta Terziroli Beretta-Piccoli / 2018 / Geoepidemiology of Primary Biliary Cholangitis: Lessons from Switzerland / Clinical Reviews in Allergy & Immunology 54(2):295~306
Invernizzi P / 2017 / Primary Biliary Cholangitis : advances in management and treatment of the disease / Dig Liver Dis 49:841~846
Kim KA / 2016 / Population-based epidemiology of primary biliary cirrhosis in South Korea / Aliment Pharmacol Ther 43:154~162
Boonstra K / 2012 / Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis : a systematic review / J Hepatol 56:1181~1188
Benedetta Terziroli Beretta-Piccoli / 2018 / Geoepidemiology of Primary Biliary Cholangitis: Lessons from Switzerland / Clinical Reviews in Allergy & Immunology 54(2):295~306
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