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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 736 - 741 (6page)
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An excessive alcohol intake may result in fatty liver, acute/chronic hepatitis, cirrhosis, and lead to hepatocellular carcinoma (HCC). The aim of this review is to clarify the present condition and the mechanisms of alcohol-related hepatocarcinogenesis and clinical risk factors for alcohol-related HCC. There are several possible mechanisms through which alcohol may induce hepatocarcinogenesis, including the mutagenic effects of acetaldehyde toxicity through the formation of protein and DNA adducts and the production of reactive oxygen species due to the excessive hepatic deposition of iron, changes to lipid peroxidation and metabolism, inflammation and an impaired immune response and modifications to DNA methylation. Furthermore, it has been reported that alcohol accelerates liver carcinogenesis through several signaling pathways including gut-liver axis. From a clinical perspective, it is well known that alcohol interacts with other factors, such as age, gender, viral hepatitis, obesity, and diabetes leading to an increased risk of HCC.
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참고문헌 (35)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
Testino G / 2014 / Alcohol and hepatocellular carcinoma : a review and a point of view / World J Gastroenterol 20:15943~15954
Hlady RA / 2014 / Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis / Oncotarget 5:9425~9443
Matsushita H / 2019 / Alcohol and hepatocellular carcinoma / BMJ Open Gastroenterol 6:e000260
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
Testino G / 2014 / Alcohol and hepatocellular carcinoma : a review and a point of view / World J Gastroenterol 20:15943~15954
Hlady RA / 2014 / Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis / Oncotarget 5:9425~9443
Matsushita H / 2019 / Alcohol and hepatocellular carcinoma / BMJ Open Gastroenterol 6:e000260
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