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논문 기본 정보

자료유형
학술저널
저자정보
Park Hana (Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine S) 신승각 (Department of Internal Medicine Gachon University Gil Medical Center Gachon University College of M) 주이진 (서울대학교병원) Song Do Seon (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea) Jang Jeong Won (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea) Park Joong-Won (Center for Liver Cancer National Cancer Center Goyang Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제14권 제6호
발행연도
2020.1
수록면
792 - 807 (16page)

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Background/Aims: Multiple meta-analyses and observational studies have reported that alcohol is a risk factor for liver cancer. However, whether there is a safe level of alcohol consumption remains unclear. We performed a systematic review and meta-analysis of the correlation between low-level alcohol consumption and the risk of liver cancer. Methods: Nested case-control studies and cohort studies involving the general population published prior to July 2019 were searched. In total, 28 publications (31 cohorts) with 4,899 incident cases and 10,859 liver cancer-related deaths were included. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: Compared with those with low levels of alcohol consumption, moderate and heavy drinkers (≥1 drink/day for females and ≥2 drinks/day for males) had pooled ORs of 1.418 (95% CI, 1.192 to 1.687; p<0.001) for liver cancer incidence and 1.167 (95% CI, 1.056 to 1.290; p=0.003) for liver cancer mortality. The pooled OR for liver disease-related mortality for those with more than low levels of alcohol consumption was 3.220 (95% CI, 2.116 to 4.898; p<0.001) and that for all-cause mortality was 1.166 (95% CI, 1.065 to 1.278; p=0.001). The sensitivity analysis showed that none of the studies had a strong effect on the pooled OR. The Egger test, Begg rank correlation test, and the funnel plot showed no overt indication of publication bias. Conclusions: Continuous consumption of more than a low-level of alcohol (≥1 drink/day for females and ≥2 drinks/ day for males) is related to a higher risk of liver cancer.

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