지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호
- 발행연도
- 2015.1
- 수록면
- 4,803 - 4,812 (10page)
이용수
초록· 키워드
오류제보하기
Chronic alcohol and tobacco abuse plays a crucial role in the development of different liver associated disorders. Intake promotes the generation of reactive oxygen species within hepatic cells exposing their DNA to continuous oxidative stress which finally leads to DNA damage. However in response to such damage an entangled protective repair machinery comprising different repair proteins like ATM, ATR, H2AX, MRN complex becomes activated. Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including hepatocellular carcinomas. The generated reactive oxygen species can also activate or repress epigenetic elements such as chromatin remodeling, non-coding RNAs (micro-RNAs), DNA (de) methylation and histone modification that affect gene expression, hence leading to various disorders. The present review provides comprehensive knowledge of different molecular mechanisms involved in gene polymorphism and their possible association with alcohol and tobacco consumption. The article also showcases the necessity of identifying novel diagnostic biomarkers for early cancer risk assessment among alcohol and tobacco users.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Molecular Screening for P53 Mutations among Tobacco Smokers in a Surveyof Awareness of Links between Tobacco, Alcohol Use and Cancer in Saudi Arabia
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Alcohol and hepatocarcinogenesis
Clinical and Molecular Hepatology
2020 .01
-
Assessment of Perception of Medical Students in Regard to Links between Tobacco or Alcohol Use and Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The development of alcohol-associated hepatocellular carcinoma mouse model
한국실험동물학회 학술발표대회 논문집
2022 .07
-
DNA damage to human genetic disorders with neurodevelopmental defects
Journal of genetic medicine
2016 .01
-
세계 담배규제정책의 흐름과 한국의 현황
대한의사협회지
2018 .01
-
Rethinking Anti-tobacco Health Education in an Eastern Mediterranean Country with Growing Tobacco Use
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Iron Supplementation Reverses the Reduction of Hydroxymethylcytosine in Hepatic DNA Associated With Chronic Alcohol Consumption in Rats
대한암예방학회지
2016 .01
-
Analysis of the global gene expression profiles in genomic instability-induced cervical cancer cells
International Journal of Oral Biology
2022 .06
-
Social Determinants of Health and Tobacco Use in Five Low - and Middle-Income Countries - Results from the Global Adult Tobacco Survey (GATS), 2011 - 2012
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The Tobacco Industry’s Abuse of Scientific Evidence and Activities to Recruit Scientists During Tobacco Litigation
예방의학회지
2016 .01
-
Targeting the DNA damage response (DDR) of cancer cells with natural compounds derived from Panax ginseng and other plants
Journal of Ginseng Research
2025 .01
-
The effect of moderate alcohol drinking in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2020 .01
-
Is Exposure to Tobacco Advertising, Promotion and Sponsorship Associated with Initiation of Tobacco Use among Current Tobacco Users in Youth in India?
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
한국의 담배규제 정책 이행 현황과 과제: WHO MPOWER를 중심으로
대한금연학회지
2023 .06
-
The effects of moderate alcohol consumption on non-alcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
Tobacco Control Stakeholder Perspectives on the Future of Tobacco Marketing Regulation in Indonesia: A Modified Delphi Study
예방의학회지
2021 .09
-
알코올 사용장애의 역학과 예방 정책
신경정신의학
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0