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Baicalin is a flavonoid compound with many advantages, including anti-inflammatory agents and antioxidants. Lipopolysaccharide (LPS) is an endotoxin that induces neuronal damage through inflammatory response and oxidative stress reaction. This study was investigated the protective effects of baicalin on the oxidative stress and histopathological changes caused by LPS in hippocampus. Adult mice were divided into four groups; vehicle-treated, baicalin-treated, LPS-treated, and LPS and baicalin co-treated animals. Baicalin (10 mg/kg/day) and/or LPS (250 μg/kg/day) were intraperitoneally administered for seven consecutive days, and body weight was measured. Reactive oxygen species (ROS) level and lipid peroxidation level in the hippocampus were examined. Histopathological study was performed using hematoxylin and eosin staining manuals. LPS treatment decreased body weight and increased ROS and oxidative stress in the hippocampus. However, co-treatment with baicalin alleviated these changes caused by LPS. Severe histopathological changes were observed in the hippocampus of LPS-treated animals. Baicalin co-treatment attenuated the changes and preserved neuronal cells from LPS damage. These results showed that baicalin suppresses LPS-induced neuronal damage by alleviating oxidative stress in the hippocampus. Thus, this study demonstrated that baicalin exerts protective effects against LPS-induced oxidative stress in hippocampus.
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참고문헌 (35)
참고문헌 신청
Bai C / 2018 / Protective effect of baicalin against severe burn‑induced remote acute lung injury in rats / Mol Med Rep 17(2):2689~2694
Banks WA / 2015 / Lipopolysaccharide-induced blood-brain barrier disruption:roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit / J Neuroinflammation 12:223
Cao Y / 2011 / Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways / Brain Res Bull 85(6):396~402
Cheng O / 2012 / Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis / Brain Res 1470:111~118
Commins S / 2001 / The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo / Neuroscience 102(2):273~280
Banks WA / 2015 / Lipopolysaccharide-induced blood-brain barrier disruption:roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit / J Neuroinflammation 12:223
Cao Y / 2011 / Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways / Brain Res Bull 85(6):396~402
Cheng O / 2012 / Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis / Brain Res 1470:111~118
Commins S / 2001 / The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo / Neuroscience 102(2):273~280
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