개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 77 - 89 (13page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Objectives: The present study was conducted to examine whether Haedoksamul-tang (HS), a traditional oriental herbal medicine, have beneficail effects on anti-inflammation and dyslipidemia in lipopolysaccharide (LPS)-induced ICR mouse.
Methods: Twenty four 8-week old male ICR mouse were divided into four groups: normal untreated; LPS treatment only; HS 10 mg/kg plus LPS treatment; and HS 30 mg/kg plus LPS treatment. HS was orally administered per day for 2days. Twenty-four hours after LPS injection (10 mg/kg/day, i.p.), all the mice were sacrificed, and serological changes were evaluated. The levels of nuclear factor-κB (NF-κB), sterol regulatory element-binding transcription protein 1 (SREBP-1) activity and cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor a (TNF-a), monocyte chemotactic protein 1 (MCP-1), acetyl-CoA carboxylase a (ACCa) expression were analyzed in Western blot analysis.
Results: HS inhibited oxidative stress in the liver of LPS-induced ICR mice. The LPS-induced ICR mice exhibited the increase of NF-κB activity and COX-2, iNOS, TNF-a, MCP-1 expressions in the liver, while HS treatment significantly inhibited them. Moreover, The administration of HS significantly decreased the elevated serum triglyceride and down-regulated the levels of SREBP-1, ACCa in the liver of LPS-induced ICR mice.
Conclusions: In conclusion, HS could have hepato-protective effects against the oxidative stress-related inflammation and abnormal lipid metabolism.
Methods: Twenty four 8-week old male ICR mouse were divided into four groups: normal untreated; LPS treatment only; HS 10 mg/kg plus LPS treatment; and HS 30 mg/kg plus LPS treatment. HS was orally administered per day for 2days. Twenty-four hours after LPS injection (10 mg/kg/day, i.p.), all the mice were sacrificed, and serological changes were evaluated. The levels of nuclear factor-κB (NF-κB), sterol regulatory element-binding transcription protein 1 (SREBP-1) activity and cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor a (TNF-a), monocyte chemotactic protein 1 (MCP-1), acetyl-CoA carboxylase a (ACCa) expression were analyzed in Western blot analysis.
Results: HS inhibited oxidative stress in the liver of LPS-induced ICR mice. The LPS-induced ICR mice exhibited the increase of NF-κB activity and COX-2, iNOS, TNF-a, MCP-1 expressions in the liver, while HS treatment significantly inhibited them. Moreover, The administration of HS significantly decreased the elevated serum triglyceride and down-regulated the levels of SREBP-1, ACCa in the liver of LPS-induced ICR mice.
Conclusions: In conclusion, HS could have hepato-protective effects against the oxidative stress-related inflammation and abnormal lipid metabolism.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (41)
참고문헌 신청
Johan F. Immunity, atherosclerosis and cardiovascular disease. BMC med. 2013;11: 117-29.
Feng X, Zhang Y, Xu R, Xie X, Tao L, Gao H, et al. Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody comples to activated human macrophages. Atherosclerosis. 2010;208: 396-405.
Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, et al. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010;107:56-65.
Maitra U, Li L. Molecular mechanisms responsible for the ruduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Arterioscler Thromb Vasc Biol. 2013;33:24-33.
Vikatmaa P, Lajunen T, Ikonen TS, Pussinen PJ, Leinonen M, Saikku P, et al. Chlamydial lipopolysaccharide (cLPS) is present in atherosclerotic and aneurysmal arterial wall--cLPS levels depend on disease manifestation. Cardiovasc Pathol. 2010;19(1):48-54.
Feng X, Zhang Y, Xu R, Xie X, Tao L, Gao H, et al. Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody comples to activated human macrophages. Atherosclerosis. 2010;208: 396-405.
Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, et al. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010;107:56-65.
Maitra U, Li L. Molecular mechanisms responsible for the ruduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Arterioscler Thromb Vasc Biol. 2013;33:24-33.
Vikatmaa P, Lajunen T, Ikonen TS, Pussinen PJ, Leinonen M, Saikku P, et al. Chlamydial lipopolysaccharide (cLPS) is present in atherosclerotic and aneurysmal arterial wall--cLPS levels depend on disease manifestation. Cardiovasc Pathol. 2010;19(1):48-54.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators
Toxicological Research
2018 .01
-
Cardiotoxicity in ICR mice of different sources : comparative study
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Comparison of cancer development to treatment of DMBA and TPA in three stocks of ICR mice derived from three different sources
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Anti-inflammatory effect of the extract of lagerstroemia ovalifolia on lipopolysaccharide-induced acute lung injury in mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
LPS-stimulated Macrophage Activation Affects Endothelial Dysfunction
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .03
-
LPS-induced animal model
한국실험동물학회 학술발표대회 논문집
2015 .08
-
LPS로 유발한 장염증 모델에 대한 주초황금의 항산화 조절 및 장염증 개선 효과
대한본초학회지(본초분과학회지)
2015 .01
-
Gender differences in the streptozotocin-induced type 2 diabetic ICR mouse models
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Comparison of the response using ICR mice derived from three different sources to high fat diet-induced hyperlipidemia
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Anti-inflammatory Effects of Ethanol Extract of Various Korean Compositae Herbs in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
Comparison of the response using ICR mice derived from three different sources to high fat diet-induced obesity
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Anti-oxidative effect of baicalin in lipopolysaccharide-induced hippocampus damage
예방수의학회지
2020 .01
-
Hepatotoxic response to acetaminophen challenge in Korl:ICR mouse
한국실험동물학회 학술발표대회 논문집
2019 .07
-
LPS로 유도한 염증반응에서 해죽순의 항염증 효과
대한본초학회지(본초분과학회지)
2016 .01
-
LPS로 유발한 RAW264.7 세포 염증반응에 대한 가감통순산(加減通順散)의 억제 효과
한방재활의학과학회지
2018 .01
-
Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages
The Korean Journal of Physiology & Pharmacology
2021 .09
-
Characterization of Korl:ICR as a HFMCD-induced NAFLD model
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Anti-inflammatory Effects of Ethanol Extract of Korean Medicinal Plants at Hwaak Mountain in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
Preparation and Evaluation of a New Lipopolysaccharide-based Conjugate as a Vaccine Candidate for Brucellosis
Osong Public Health and Research Persptectives
2015 .02
-
The Role of IL-17 in a Lipopolysaccharide-Induced Rhinitis Model
Allergy, Asthma & Immunology Research
2017 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
산화스트레스가 유도된 HepG2 세포에서 Eriodictyol의 항산화 효과
주태우
,
홍성현
,
박선영
외 2명
한국식품영양과학회지
2016
.04
싸리나무(Lespedeza bicolor) 부위별 추출물의 항산화 활성 및 항산화물질 분리
이재학
,
주진우
한국식품과학회지
2012
.12
한국인 상용식품의 플라보노이드 데이터베이스 구축
양윤경
,
김지연
,
권오란
한국영양학회지
2012
.06
쑥의 에탄올 추출물에 함유된 Flavonoid들의 분리 및 동정과 이들의 항산화 효과
이상준
,
정하열
,
이인경
외 1명
한국식품과학회지
1999
.06
식물생리활성영양소와 미용기능식품
김은아
식품과학과 산업
2007
.12
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-519-002699482