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논문 기본 정보

자료유형
학술저널
저자정보
Cheolmin Shin (Korea University) Chi-Un Pae (The Catholic University of Korea) Kyung Phil Kwak (Department of Psychiatry Dongguk University Gyeongju Hospital) Sang Won Jeon (Department of Psychiatry Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine) Hyun-Ghang Jeong (Korea University) Jong Woo kim (Department of Psychiatry Kyung Hee University Hospital Seoul) Youn Jung Lee (Gyeongsang National University) Ashwin A. Patkar (Duke University Medical Center) Changsu Han (Korea University)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제2호
발행연도
2021.1
수록면
243 - 253 (11page)

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Objective: Many patients with major depressive disorder (MDD) suffer from residual symptoms without achieving remission. However, pharmacologic options for residual symptoms of MDD have been limited. This study aimed to investigate benefit of aripiprazole augmentation in the treatment of residual symptoms in the patients with partially remitted MDD. Methods: We retrospectively analyzed the 8-week medical records of the patients. The enrolled patients did respond to treatment of antidepressant but were not remitted. The range of 17-item Hamilton Depression Rating Scale (HAMD) total score of the subjects were 8 to 15 points. All patients were currently taking antidepressants when they started aripiprazole. The primary endpoint was the mean change of Clinically Useful Depression Outcome Scale (CUDOS). Secondary endpoint measures were HAMD, Clinical Global Impression-severity (CGI-S) scores, Patient Health Questionnaire-15 (PHQ-15), Beck Anxiety Inventory (BAI), Perceived Deficit Questionnaire-depression (PDQ-D), Sheehan Disability Scale (SDS) and General Health Questionnaire/Quality of Life-12 (GHQ/QL-12). Results: A total of 134 medical records were analyzed. The changes of CUDOS, HAMD, CGI-S, BAI, PHQ-15, PDQ-D, SDS and GHQ/QL-12 from baseline to the endpoint were ?7.93, ?3.29, ?0.80, ?4.02, ?2.05, ?4.35, ?4.77 and ?2.82, respectively (all p ＜ 0.001). At the endpoint, the newly remitted subjects rate by HAMD score criteria were approximately 46%. Conclusion: Our preliminary findings have presented the effectiveness of aripiprazole augmentation for residual symptoms of partially remitted MDD patients in routine practice. This study assures subsequent well-controlled studies of the possibility of generalizing the above promising outcome in the future.
#Residual symptom #Major depressive disorder #Antidepressant #Aripiprazole augmentation

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참고문헌 (61)

참고문헌 신청
Trivedi MH / 2006 / Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D : implications for clinical practice / Am J Psychiatry 163:28~40 google schola Frank E / 1991 / Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence / Arch Gen Psychiatry 48:851~855 google schola Riso LP / 1997 / A prospective test of criteria for response, remission, relapse, recovery, and recurrence in depressed patients treated with cognitive behavior therapy / J Affect Disord 43:131~142 google schola Riedel M / 2010 / Response and remission criteria in major depression : a validation of current practice / J Psychiatr Res 44:1063~1068 google schola McClintock SM / 2011 / Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication / J Clin Psychopharmacol 31:180~186 google schola

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