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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제1호
- 발행연도
- 2016.1
- 수록면
- 1 - 16 (16page)
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Cognitive deficits in major depressive disorder (MDD) patients have been described in numerous studies. However, few reports have aimed to describe cognitive deficits in the remitted state of MDD and the mediational effect of cognitive deficits on occupational outcome. The aim of the current review is to synthesize the literature on the mediating and moderating effects of specific domains of cognition on occupational impairment among people with remitted MDD. In addition, predictors of cognitive deficits found to be vocationally important will be examined. Upon examination of the extant literature, attention, executive function and verbal memory are areas of consistent impairment in remitted MDD patients. Cognitive domains shown to have considerable impact on vocational functioning include deficits in memory, attention, learning and executive function. Factors that adversely affect cognitive function related to occupational accommodation include higher age, late age at onset, residual depressive symptoms, history of melancholic/psychotic depression, and physical/psychiatric comorbidity, whereas higher levels of education showed a protective effect against cognitive deficit. Cognitive deficits are a principal mediator of occupational impairment in remitted MDD patients. Therapeutic interventions specifically targeting cognitive deficits in MDD are needed, even in the remitted state, to improve functional recovery, especially in patients who have a higher risk of cognitive deficit.
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참고문헌 (140)
참고문헌 신청
Hamet P / 2005 / Genetics and genomics of depression / Metabolism 54(5 Suppl 1):10~15
Kessler RC / 2003 / The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) / JAMA 289:3095~3105
Bakish D / 2001 / New standard of depression treatment : remission and full recovery / J Clin Psychiatry 62(Suppl 26):5~9
Hirschfeld RM / 2002 / Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination / Biol Psychiatry 51:123~133
Miller IW / 1998 / The treatment of chronic depression, part 3: psychosocial functioning before and after treatment with sertraline or imipramine / J Clin Psychiatry 59:608~619
Kessler RC / 2003 / The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) / JAMA 289:3095~3105
Bakish D / 2001 / New standard of depression treatment : remission and full recovery / J Clin Psychiatry 62(Suppl 26):5~9
Hirschfeld RM / 2002 / Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination / Biol Psychiatry 51:123~133
Miller IW / 1998 / The treatment of chronic depression, part 3: psychosocial functioning before and after treatment with sertraline or imipramine / J Clin Psychiatry 59:608~619
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