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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제4호
- 발행연도
- 2020.1
- 수록면
- 621 - 626 (6page)
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Objective: To test clinical effectiveness and tolerability of Korean Red Ginseng augmentation (RGA) in major depressive disorder (MDD) patients with difficult-to-treat. Methods: Thirty six patients were enrolled in this 6 weeks, prospective, clinical trial. Rating scales were MontgomeryAsberg Depression Rating Scale (MADRS), Patient Health Questionnaire-15, Clinical Global Impression-improvement (CGI-I), and Patient Satisfaction Score. The primary endpoint was a remission rate measured by MADRS score at the end of study (≤ 10). Clinical outcomes and tolerability were assessed at baseline, week 2, and week 6. Results: Among 36 patients, 26 patients completed the study and 28 patients had post-baseline visit data. The remission rate by MADRS score was 39.3% (11/28) and 57.1% by CGI-I scores of 1 or 2 at the end of the study. The mean change of MADRS score was significantly decreased by 44.4% from baseline to the end of study. The most frequent adverse events were headache (7/28, 25.0%) during the study. Conclusion: Our study indicates the putative effectiveness and tolerability of RGA for treating MDD with difficult-to-treat in clinical practice. However, adequately powered, randomized, controlled trials will be needed to confirm these results.
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참고문헌 (35)
참고문헌 신청
Changsu Han / 2018 / A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial / Clinical Psychopharmacology and Neuroscience 16(4):469~480
Alessandro Serretti / 2018 / The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants / Clinical Psychopharmacology and Neuroscience 16(1):1~6
Gaynes BN / 2009 / What did STAR*D teach us? Results from a largescale, practical, clinical trial for patients with depression / Psychiatr Serv 60:1439~1445
Chiara Fabbri / 2020 / Genetics of Treatment Outcomes in Major Depressive Disorder: Present and Future / Clinical Psychopharmacology and Neuroscience 18(1):1~9
Rush AJ / 2007 / STAR*D: what have we learned? / Am J Psychiatry 164:201~204
Alessandro Serretti / 2018 / The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants / Clinical Psychopharmacology and Neuroscience 16(1):1~6
Gaynes BN / 2009 / What did STAR*D teach us? Results from a largescale, practical, clinical trial for patients with depression / Psychiatr Serv 60:1439~1445
Chiara Fabbri / 2020 / Genetics of Treatment Outcomes in Major Depressive Disorder: Present and Future / Clinical Psychopharmacology and Neuroscience 18(1):1~9
Rush AJ / 2007 / STAR*D: what have we learned? / Am J Psychiatry 164:201~204
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