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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제1호
- 발행연도
- 2021.1
- 수록면
- 112 - 116 (5page)
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초록· 키워드
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Objective: Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia. Methods: The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants. Results: The patients with schizophrenia had higher MHR values (15.04 ± 3.31 in schizophrenia patients and 12.62 ± 2.99 in controls; p = 0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, body mass index, severity of disease and MHR. Conclusion: To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.
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참고문헌 (29)
참고문헌 신청
Filiz Karadag / 2017 / Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders / Clinical Psychopharmacology and Neuroscience 15(2):153~162
Miller BJ / 2011 / Meta-analysis of cytokine alterations in schizophrenia : clinical status and antipsychotic effects / Biol Psychiatry 70:663~671
Correll CU / 2017 / Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness : a large-scale meta-analysis of 3, 211, 768 patients and 113, 383, 368 controls / World Psychiatry 16:163~180
Qiu C / 2015 / A major role for cardiovascular burden in age-related cognitive decline / Nat Rev Cardiol 12:267~277
Kaffashian S / 2013 / Predicting cognitive decline: a dementia risk score vs. the Framingham vascular risk scores / Neurology 80:1300~1306
Miller BJ / 2011 / Meta-analysis of cytokine alterations in schizophrenia : clinical status and antipsychotic effects / Biol Psychiatry 70:663~671
Correll CU / 2017 / Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness : a large-scale meta-analysis of 3, 211, 768 patients and 113, 383, 368 controls / World Psychiatry 16:163~180
Qiu C / 2015 / A major role for cardiovascular burden in age-related cognitive decline / Nat Rev Cardiol 12:267~277
Kaffashian S / 2013 / Predicting cognitive decline: a dementia risk score vs. the Framingham vascular risk scores / Neurology 80:1300~1306
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