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논문 기본 정보

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학술저널
저자정보
Ha Jang Woo (Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea) Ahn Sung Soo (Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) 송정식 (Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College o) 박영범 (Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College o) 이상원 (Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College o)
저널정보
대한류마티스학회 대한류마티스학회지 Journal of Rheumatic Diseases Vol.31 No.3
발행연도
2024.7
수록면
151 - 159 (9page)
DOI
10.4078/jrd.2024.0001

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Objective: In this study, the association between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) at diagnosis and poor outcomes of atherosclerosis-related antineutrophil cytoplasmic antibody-associated vasculitis (AAV) during follow-up in patients with AAV was investigated. Methods: This retrospective study included 138 patients diagnosed with AAV. Their comprehensive medical records were meticulously reviewed. All-cause mortality, cerebrovascular accident (CVA), and acute coronary syndrome (ACS) were evaluated as atherosclerosis-related poor outcomes of AAV. MHR was obtained by dividing monocyte counts (/mm3) by high-density lipoprotein cholesterol (mg/dL) levels. Results: The median age of the 138 patients was 58.3 years with 44 being male (31.9%). Among the 138 patients, 11 (8.0%) died, and 11 (8.0%) and 9 (6.5%) had CVA, and ACS, respectively. MHR at diagnosis was significantly correlated with the Birmingham vasculitis activity score, erythrocyte sedimentation rate, and C-reactive protein at diagnosis. Among the three poor outcomes of AAV, only CVA during follow-up was significantly associated with MHR at diagnosis, and thus, only CVA was considered an atherosclerosis-related poor outcome of AAV. In the multivariable Cox hazards model analysis, MHR (hazard ratio [HR]: 1.195) and serum albumin (HR: 0.203) at diagnosis were independently associated with CVA during follow-up. Additionally, patients with MHR at diagnosis ≥3.0 exhibited a significantly higher risk for CVA and lower cumulative CVA-free survival rate than those with MHR at diagnosis <3.0. Conclusion: This study is the first to demonstrate clinical implications of MHR suggesting that MHR at diagnosis is significantly and independently associated with CVA during follow-up in patients with AAV.
#Monocytes #High density lipoprotein cholesterol #Stroke #Antineutrophil cytoplasmic antibody #Vasculitis

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