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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 226 - 229 (4page)
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S100A8 functions as an essential factor in inflammatory response. Cytokine release of monocytes and regulation of neutrophil apoptosis are important steps in pathogenesis of allergy. This study aims to examine the relation between cytokine release of monocytes due to S100A8 and neutrophil apoptosis. S100A8 enhanced the release of IL-6 and IL-8 in monocytes of normal and allergic subjects. Treatment of supernatants of normal and allergic monocytes with S100A8 blocked neutrophil apoptosis by inhibition of caspase 9 and caspase 3 activation. The secretion signal induced by S100A8 is involved in TLR4, Src family protein, PKCδ, ERK1/2, p38 MAPK, JNK, and NF-κB. These findings may contribute to understanding the complex pathogenesis of allergic diseases by determining inflammatory responses associated with S100A8, monocytes, and neutrophils.
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참고문헌 (12)
참고문헌 신청
Donato R / 2013 / Functions of S100 proteins / Current Molecular Medicine 13:24~57
Fassl SK / 2015 / Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8 / Journal of Immunology 194:575~583
Goyette J / 2011 / Inflammation-associated S100 proteins : new mechanisms that regulate function / Amino Acids 41:821~842
Holgate ST / 2008 / Pathogenesis of asthma / Clinicanl and Experimental Allergy 38:872~897
Jin S / 2014 / DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis / Experimental Dermatology 23:938~941
Fassl SK / 2015 / Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8 / Journal of Immunology 194:575~583
Goyette J / 2011 / Inflammation-associated S100 proteins : new mechanisms that regulate function / Amino Acids 41:821~842
Holgate ST / 2008 / Pathogenesis of asthma / Clinicanl and Experimental Allergy 38:872~897
Jin S / 2014 / DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis / Experimental Dermatology 23:938~941
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UCI(KEPA) : I410-ECN-0101-2020-510-001305963