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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 409 - 413 (5page)
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초록· 키워드
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Epidemiological studies of monoclonal B-cell lymphocytosis (MBL) have been conducted in limited geographical regions. Little is known about the prevalence of MBL in Asia. We investigated the prevalence and immunophenotypic characteristics of MBL in Koreans who had idiopathic lymphocytosis (lymphocyte count >4.0×109/L) and were ≥40 years of age. A total of 105 leftover peripheral blood samples met these criteria among those from 73,727 healthy individuals who visited the Health Promotion Center, Samsung Medical Center, Korea, from June 2018 to August 2019. The samples were analyzed using eight-color flow cytometry with the following monoclonal antibodies: CD45, CD5, CD10, CD19, CD20, CD23, and kappa and lambda light chains. The overall prevalence of MBL in the study population was 2.9% (3/105); there was one case of chronic lymphocytic leukemia (CLL)-like MBL (CD5+CD23+), one case of atypical CLL-like MBL (CD5+CD23?), and one case of CD5?MBL with a lambda restriction pattern. This is the first study on the MBL prevalence in an East Asian population, and it reveals a relatively low prevalence of MBL in healthy Korean individuals with lymphocytosis.
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참고문헌 (19)
참고문헌 신청
Landgren O / 2009 / B-cell clones as early markers for chronic lymphocytic leukemia / N Engl J Med 360:659~667
Shim YK / 2010 / Prevalence of monoclonal B-cell lymphocytosis: a systematic review / Cytometry B Clin Cytom 78(S1):S10~S18
Criado I / 2018 / Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome / Haematologica 103:1198~1208
Marti GE / 2005 / Diagnostic criteria for monoclonal B-cell lymphocytosis / Br J Haematol 130:325~332
Nieto WG / 2009 / Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach / Blood 114:33~37
Shim YK / 2010 / Prevalence of monoclonal B-cell lymphocytosis: a systematic review / Cytometry B Clin Cytom 78(S1):S10~S18
Criado I / 2018 / Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome / Haematologica 103:1198~1208
Marti GE / 2005 / Diagnostic criteria for monoclonal B-cell lymphocytosis / Br J Haematol 130:325~332
Nieto WG / 2009 / Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach / Blood 114:33~37
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