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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 552 - 557 (6page)
- DOI
- https://doi.org/10.3803/EnM.2022.1421
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초록· 키워드
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Sestrin2, a well-known adenosine monophosphate-activated protein kinase (AMPK) regulator, plays a protective role against metabolic stress. The β3-adrenergic receptor (β3AR) induces fat browning and inhibits muscle atrophy in an AMPK-dependent manner.
However, no prior research has examined the relationship of sestrin2 with β3AR in body composition changes. In this study, CL316,243 (CL), a β3AR agonist, was administered to wild-type and sestrin2-knockout (KO) mice for 2 weeks, and fat and muscle tissues were harvested. CL induced AMPK phosphorylation, expression of brown-fat markers, and mitochondrial biogenesis, whichresulted in the reduction of lipid droplet size in inguinal white adipose tissue (iWAT). These effects were not observed in sestrin2-KO mice. In CL-treated soleus muscle, sestrin2-KO was related to decreased myogenic gene expression and increased levels ofmuscle atrophy-related molecules. Our results suggest that sestrin2 is associated with beneficial β3AR-mediated changes in bodycomposition, especially in iWAT and in the soleus.
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