Healthy versus Unhealthy Adipose Tissue Expansion: the Role of Exercise

Benjamin M. Meister; Soon-Gook Hong; Junchul Shin; Meghan Rath; Jacqueline Sayoc; 박준영

doi:10.7570/jomes21096

추천

검색

자료유형: 학술저널

저자정보: Benjamin M. Meister (Department of Kinesiology College of Public Health and Cardiovascular Research Center) Soon-Gook Hong (Department of Kinesiology College of Public Health and Cardiovascular Research Center) Junchul Shin (Department of Kinesiology College of Public Health and Cardiovascular Research Center) Meghan Rath (Department of Kinesiology College of Public Health and Cardiovascular Research Center) Jacqueline Sayoc (Department of Kinesiology College of Public Health and Cardiovascular Research Center) 박준영 (Temple University)

저널정보: 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.31 No.1

발행연도: 2022.3

수록면: 37 - 50 (14page)

DOI: 10.7570/jomes21096

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Although the hallmark of obesity is the expansion of adipose tissue, not all adipose tissue expansion is the same. Expansion of healthy adipose tissue is accompanied by adequate capillary angiogenesis and mitochondria-centered metabolic integrity, whereas expansion of unhealthy adipose tissue is associated with capillary and mitochondrial derangement, resulting in deposition of immune cells (M1-stage macrophages) and excess production of pro-inflammatory cytokines. Accumulation of these dysfunctional adipose tissues has been linked to the development of obesity comorbidities, such as type 2 diabetes, hypertension, dyslipidemia, and cardiovascular disease, which are leading causes of human mortality and morbidity in modern society. Mechanistically, vascular rarefaction and mitochondrial incompetency (for example, low mitochondrial content, fragmented mitochondria, defective mitochondrial respiratory function, and excess production of mitochondrial reactive oxygen species) are frequently observed in adipose tissue of obese patients. Recent studies have demonstrated that exercise is a potent behavioral intervention for preventing and reducing obesity and other metabolic diseases. However, our understanding of potential cellular mechanisms of exercise, which promote healthy adipose tissue expansion, is at the beginning stage. In this review, we hypothesize that exercise can induce unique physiological stimuli that can alter angiogenesis and mitochondrial remodeling in adipose tissues and ultimately promote the development and progression of healthy adipogenesis. We summarize recent reports on how regular exercise can impose differential processes that lead to the formation of either healthy or unhealthy adipose tissue and discuss key knowledge gaps that warrant future research.

#Exercise #Adipose tissue #Angiogenesis #Mitochondrion

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!