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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제5호
- 발행연도
- 2020.1
- 수록면
- 395 - 402 (8page)
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초록· 키워드
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This study has investigated the effect of a potent bioflavonoid, troxerutin, on diabetes-induced changes in pro-inflammatory mediators and expression of microRNA-146a and nuclear factor-kappa-B (NF-κB) signaling pathway in aortic tissue of type-I diabetic rats. Male Wistar rats were randomly divided into four groups (n = 6/each): healthy, healthy-troxerutin, diabetic, and diabetic-troxerutin. Diabetes was induced by streptozotocin injection (60 mg/kg; intraperitoneally) and lasted 10 weeks. Troxerutin (150 mg/kg/day) was administered orally for last month of experiment. Inflammatory cytokines IL-1?, IL-6, and TNF-?, as well as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule (VCAM), cyclooxygenase-II (COX-II), and inducible-nitric oxide synthase (iNOS) were measured on aortic samples by enzyme-linked immunosorbent assay. Gene expressions for transcription factor NF-κB, interleukin-1 receptor-associated kinase-1 (IRAK-1), TNF receptor-associated factor-6 (TRAF-6), and microRNA-146a were determined using real-time polymerase chain reaction. Ten-week diabetes significantly increased mRNA levels of IRAK-1, TRAF-6, NF-κB, and protein levels of cytokines IL-1?, IL-6, TNF-?, adhesion molecules ICAM-1, VCAM, and iNOS, COX-II, and decreased expression of microRNA-146a as compared with healthy rats (p < 0.05 to p < 0.01). However, one month treatment of diabetic rats with troxerutin restored glucose and insulin levels, significantly decreased expression of inflammatory genes and pro-inflammatory mediators and increased microRNA level in comparison to diabetic group (p < 0.05 to p < 0.01). In healthy rats, troxerutin had significant reducing effect only on NF-κB, TNF-? and COXII levels (p < 0.05). Beside slight improvement of hyperglycemia, troxerutin prevented the activation of NF-κB-dependent inflammatory signaling in the aorta of diabetic rats, and this response may be regulated by microRNA-146a
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참고문헌 (32)
참고문헌 신청
Rask-Madsen C / 2013 / Vascular complications of diabetes : mechanisms of injury and protective factors / Cell Metab 17:20~33
Nicholls SJ / 2008 / Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling : a pooled analysis of 5intravascular ultrasound trials / J Am Coll Cardiol 52:255~262
Shi Y / 2017 / Macro-and microvascular endothelial dysfunction in diabetes / J Diabetes 9:434~449
Yuan T / 2019 / New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis / Redox Biol 20:247~260
Kantharidis P / 2011 / Diabetes complications : the microRNA perspective / Diabetes 60:1832~1837
Nicholls SJ / 2008 / Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling : a pooled analysis of 5intravascular ultrasound trials / J Am Coll Cardiol 52:255~262
Shi Y / 2017 / Macro-and microvascular endothelial dysfunction in diabetes / J Diabetes 9:434~449
Yuan T / 2019 / New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis / Redox Biol 20:247~260
Kantharidis P / 2011 / Diabetes complications : the microRNA perspective / Diabetes 60:1832~1837
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