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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 70 - 76 (7page)
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초록· 키워드
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Background and Purpose We aimed to determine the relationships of 33 biomarkers of inflammation, oxidation, and adipokines with the risk of progression of symptomatic intracranial atherosclerotic stenosis (ICAS). Methods Fifty-two of 409 patients who participated in the TOSS-2 (Trial of Cilostazol in Symptomatic Intracranial Stenosis-2) showed progression of symptomatic ICAS in magnetic resonance angiography at 7 months after an index stroke. We randomly selected 20 patients with progression as well as 40 age- and sex-matched control patients. We serially collected blood samples at baseline, 1 month, and 7 months after an index stroke. Multiplex analysis of biomarkers was then performed. Results Demographic features and risk factors such as hypertension, diabetes, and smoking history were comparable between the two groups. Univariate analyses revealed that the levels of platelet-derived growth factor (PDGF)-AA [median (interquartile range)=1.64 (0.76?4.57) vs. 0.77 (0.51?1.71) ng/mL], PDGF-AB/BB [10.31 (2.60?25.90) vs. 2.35 (0.74?6.70) ng/mL], and myeloperoxidase [10.5 (7.5?22.3) vs. 7.8 (5.5?12.2) ng/mL] at 7 months were higher in the progression group. In the multivariate analysis using logistic regression, the PDGF AB/BB level at 7 months was independently associated with the progression of ICAS (p=0.02). Conclusions The PDGF-AB/BB level is associated with the progression of ICAS, and so may play a significant role in the progression of human ICAS.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Gorelick P / 2008 / Intracranial Atherosclerosis / Wiley-Blackwell :33~44
Gorelick PB / 2008 / Large artery intracranial occlusive disease : a large worldwide burden but a relatively neglected frontier / Stroke 39:2396~2399
Moossy J / 1966 / Morphology, sites and epidemiology of cerebral atherosclerosis / Res Publ Assoc Res Nerv Ment Dis 41:1~22
Chimowitz MI / 2005 / Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis / N Engl J Med 352:1305~1316
Arenillas JF / 2001 / Progression and clinical recurrence of symptomatic middle cerebral artery stenosis : a long-term follow-up transcranial Doppler ultrasound study / Stroke 32:2898~2904
Gorelick PB / 2008 / Large artery intracranial occlusive disease : a large worldwide burden but a relatively neglected frontier / Stroke 39:2396~2399
Moossy J / 1966 / Morphology, sites and epidemiology of cerebral atherosclerosis / Res Publ Assoc Res Nerv Ment Dis 41:1~22
Chimowitz MI / 2005 / Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis / N Engl J Med 352:1305~1316
Arenillas JF / 2001 / Progression and clinical recurrence of symptomatic middle cerebral artery stenosis : a long-term follow-up transcranial Doppler ultrasound study / Stroke 32:2898~2904
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