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논문 기본 정보

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학술저널
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송윤선 (서울아산병원) Lee Dongwhane (Asan Medical Center) 서대철 (울산대학교) Joong-goo Kim (Asan Medical Center College of Medicine University of Ulsan Seoul Korea) 김재균 (중앙대학교) Minkyu Han (Department of Clinical Epidemiology and Biostatistics Asan Medical Center College of Medicine) Liu Hairi (Department of Interventional Radiology Taizhou People’s Hospital Taizhou China) Lingbo Zhao (Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing China) Eun Hye Kim (Department of Radiology Asan Medical Center Seoul Kore) Sung Chul Jung (Department of Radiology Asan Medical Center Seoul Korea) Dong-geun Lee (1Department of Radiology Asan Medical Center Seoul Korea) 구현정 (서울아산병원) Min-ju Kim (Department of Clinical Epidemiology and Biostatistics Asan Medical Center Seoul Korea) Seunghee Baek (Department of Clinical Epidemiology and Biostatistics Asan Medical Center Seoul Korea) 황선문 (서울아산병원) Bum Joon Kim (Department of Neurology Asan Medical Center Seoul Kore) Yeon-Jung Kim (Department of Neurology Asan Medical Center Seoul Korea) 조홍준 (울산대학교) 김상준 (울산대학교) Sang-Beom Jeon (Department of Neurology Asan Medical Center College of Medicine University of Ulsan Seoul Korea) Jong S. Kim (Department of Radiology Asan Medical Center College of Medicine University of Ulsan Seoul Korea)
저널정보
대한신경중재치료의학회 Neurointervention Neurointervention Vol.14 No.1
발행연도
2019.1
수록면
43 - 52 (10page)

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Purpose Cigarette smoking (CS) is one of the major risk factors of cerebral atherosclerotic disease, however, its level of contribution to extracranial and intracranial atherosclerotic stenosis (ECAS and ICAS) was not fully revealed yet. The purpose of our study was to assess the association of CS to cerebral atherosclerosis along with other risk factors. Materials and Methods All consecutive patients who were angiographically confirmed with severe symptomatic cerebral atherosclerotic disease between January 2002 and December 2012 were included in this study. Multivariate logistic regression analyses were performed to identify risk factors for ECAS and ICAS. Thereafter, CS group were compared to non-CS group in the entire study population and in a propensity-score matched population with two different age-subgroups. Results Of 1709 enrolled patients, 794 (46.5%) had extracranial (EC) lesions and the other 915 (53.5%) had intracranial (IC) lesions. CS group had more EC lesions (55.8% vs. 35.3%, P<0.001) whereas young age group (<50 years) had more IC lesion (84.5% vs. 47.6%, P<0.001). In multivariate analysis, seven variables including CS, male, old age, coronary heart disease, higher erythrocyte sedimentation rate, multiple lesions, and anterior lesion were independently associated with ECAS. In the propensity-score matched CS group had significant more EC lesion compared to non-CS group (65.7% vs. 47.9%) only in the old age subgroup. Conclusion In contrast to a significant association between CS and severe symptomatic ECAS shown in old population, young patients did not show this association and showed relatively higher preference of ICAS.
#Atherosclerosis #Risk factors #Cerebrovascular circulation #Smoking

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참고문헌 (32)

참고문헌 신청
Arenillas JF / 2011 / Intracranial atherosclerosis: current concepts / Stroke 42(1 Suppl):S20~S23 google schola Kim JS / 2009 / Intracranial atherosclerosis / John Wiley & Sons google schola Sacco RL / 1995 / Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The northern manhattan stroke study / Stroke 26:14~20 google schola Gorelick PB / 2008 / Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier / Stroke 39:2396~2399 google schola Wong LK / 2006 / Global burden of intracranial atherosclerosis / Int J Stroke 1:158~159 google schola

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