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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 499 - 507 (9page)
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Purpose This study analyzed the role of plasma biomarkers for TSU-68 in a previous phase II trial comparing TSU-68 plus docetaxel and docetaxel alone in patients with metastatic breast cancer.
Materials and Methods A total of 77 patients were eligible for this study (38!in the TSU-68 plus docetaxel arm and 39 in the docetaxel alone arm). Blood samples were collected prior to the start of each cycle, and vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)- AA, -AB, -BB, fibroblast growth factor, M30, C-reactive protein (CRP), and interleukin 6 (IL-6) levels were measured using enzyme linked immunosorbent assay. The primary endpoint was progression-free survival (PFS).
Results In patients with baseline PDGF-AA " median, median PFS was significantly worse in the TSU- 68 plus docetaxel group than in the docetaxel alone group (5.4 months vs. 13.7 months, p=0.049), while a trend toward a PFS benefit was observed in those with baseline PDGFAA < median (9.7 months vs. 4.0 months, p=0.18; p for interaction=0.03). In the TSU-68 plus docetaxel group, PFS showed significant association with fold changes in CRP (p=0.001), IL-6 (p < .001), PDGF-BB (p=0.02), and VEGF (p=0.047) following the first treatment cycle.
Conclusion Baseline PDGF-AA levels and dynamics of VEGF, PDGF-BB, CRP, and IL-6 levels were predictive for the efficacy of TSU-68.
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참고문헌 (14)
참고문헌 신청
Hicklin DJ / 2005 / Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis / J Clin Oncol 23:1011~1027
Reddy S / 2012 / Targeting angiogenesis in metastatic breast cancer / Oncologist 17:1014~1026
Laird AD / 2000 / SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors / Cancer Res 60:4152~4160
Suzuki Y / 2013 / A multicenter phase II study of TSU-68, a novel oral multiple tyrosine kinase inhibitor, in patients with metastatic breast cancer progressing despite prior treatment with an anthracycline-containing regimen and taxane / Int J Clin Oncol 18:590~597
Toi M / 2014 / A multicenter phase II study of TSU-68, an oral multiple tyrosine kinase inhibitor, in combination with docetaxel in metastatic breast cancer patients with anthracycline resistance / Breast Cancer 21:20~27
Reddy S / 2012 / Targeting angiogenesis in metastatic breast cancer / Oncologist 17:1014~1026
Laird AD / 2000 / SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors / Cancer Res 60:4152~4160
Suzuki Y / 2013 / A multicenter phase II study of TSU-68, a novel oral multiple tyrosine kinase inhibitor, in patients with metastatic breast cancer progressing despite prior treatment with an anthracycline-containing regimen and taxane / Int J Clin Oncol 18:590~597
Toi M / 2014 / A multicenter phase II study of TSU-68, an oral multiple tyrosine kinase inhibitor, in combination with docetaxel in metastatic breast cancer patients with anthracycline resistance / Breast Cancer 21:20~27
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