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논문 기본 정보

자료유형
학술저널
저자정보
Fatemeh Alsadat Rahnemaei (Shahid Beheshti University of Medical Sciences) Ali Gholamrezaei (The University of Sydney) Maryam Afrakhteh (Shahid Beheshti University of Medical Sciences) Farid Zayeri (Department of Biostatistics Faculty of Paramedical Shahid Beheshti University of Medical Sciences) Mohammadreza Vafaei (Universiti Teknologi Malaysia) Arian Rashidi (Shohadae Tajrish Hospital) Giti Ozgoli (Shahid Beheshti University of Medical Sciences)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제64권 제4호
발행연도
2021.1
수록면
353 - 363 (11page)

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ObjectiveRecent studies have shown a possible association between vitamin D deficiency and the severity of primarydysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemicsymptoms in patients with primary dysmenorrhea. MethodsThis double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years withprimary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IUof vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes werepain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), andseverity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12). ResultsCompared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity(-1.0 and -1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (-1.0 day at weeks 4 and 8, P<0.001), thenumber of consumed pain-relief medications (-1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (-1.0 scoreat weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes. ConclusionVitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemicsymptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.

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