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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 89 - 93 (5page)
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초록· 키워드
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Objective: To determine the effects of multivitamin vitamin D 300 or 600 units on serum 25 hydroxyvitamin D (25(OH)D) level after 4 weeks of supplementation in postmenopausal women with vitamin D insufficiency. Study design: Randomized double-blind, placebo-controlled trial. Methods: Postmenopausal women who had vitamin D insufficiency were recruited into the study. The participants were randomized to 3 groups of 4-week treatment period with multivitamin (GPO, Governmental Pharmacy Organization) 2 tablets (contained vitamin D2 amount 600 units), multivitamin 1 tablet (contained vitamin D2 amount 300 units) or placebo. At baseline and after 4 weeks of supplementation, serum 25(OH)D were determined with electrochemilumines-cence immunoassay (Cobas, Roche Diagnostics) and level change of 25(OH)D level were compared among the groups. Results: Out of 144 participants, 49.3% had vitamin D deficiency (<20 ng/ml) and 50.7% had vitamin D insufficiency (<30 ng/ml). However, after 4 weeks of the GPO oral multivitamin, serum 25(OH)D levels significantly increased from 19.4 ± 6.3 ng/ml at baseline to 22.2 ± 5.2 ng/ml (P ¼ 0.01) and from 19.5 ± 5.0 ng/ml to 23.3 ± 5.2 ng/ml (P < 0.01) in the groups receiving vitamin D 300 IU and 600 IU/day, respectively. Approximately, 10% of those who took vitamin D had serum 25(OH)D level above the insufficiency level within 4 weeks. There was no significant changes of serum 25(OH)D after 4 weeks in the placebo group. Conclusion: Daily supplementation of the generic multivitamin containing vitamin D2 300 and 600 IU daily for 4 weeks significantly increased mean serum 25(OH)D from baseline up above the deficiency level. Thai clinical trials registration: URL: http://www.clinicaltrials.in.th. Identification number: TCTR20131206001. © 2016 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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참고문헌 (16)
참고문헌 신청
Holick MF / 2011 / Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline / J Clin Endocrinol Metabolism 96(7):1911~1930
Consensus development conference / 1993 / diagnosis, prophylaxis, and treatment of osteoporosis / Am J Med 94(6):646~650
Chailurkit LO / 2011 / Vitamin D status and bone health in healthy Thai elderly women / Nutr Burbank, Los Angel Cty Calif 27(2):160~164
Greenspan SL / 2005 / Vitamin D supplementation in older women. The journals of gerontology Series A / Biol Sci Med Sci 60(6):754~759
Soontrapa S / 2009 / Vitamin D status of Thai premenopausal women / J Med Assoc ThailChotmaihet thangphaet 92(Suppl5):S17~S20
Consensus development conference / 1993 / diagnosis, prophylaxis, and treatment of osteoporosis / Am J Med 94(6):646~650
Chailurkit LO / 2011 / Vitamin D status and bone health in healthy Thai elderly women / Nutr Burbank, Los Angel Cty Calif 27(2):160~164
Greenspan SL / 2005 / Vitamin D supplementation in older women. The journals of gerontology Series A / Biol Sci Med Sci 60(6):754~759
Soontrapa S / 2009 / Vitamin D status of Thai premenopausal women / J Med Assoc ThailChotmaihet thangphaet 92(Suppl5):S17~S20
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