지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 278 - 285 (8page)
이용수
초록· 키워드
오류제보하기
Background: Previous randomized controlled trials (RCTs) have reported inconsistent findings regarding the association between vitamin C supplementation and the risk of cancer.
Methods: We performed a meta-analysis of RCTs to investigate the efficacy of vitamin C supplements for prevention of cancer. We searched the PubMed, EMBASE, and Cochrane Library databases in November 2014 using common keywords related to vitamin C supplements and cancer.
Results: Among 785 articles, a total of seven trials were identified, which included 62,619 participants; 31,326 and 31,293 were randomized to vitamin C supplementation and control or placebo groups, respectively, which were included in the final analysis. A fixed-effects meta-analysis of all seven RCTs revealed no significant association between vitamin C supplementation and cancer (relative risk, 1.00; 95% confidence intervals, 0.95–1.05). Similarly, subgroup meta-analysis by dose of vitamin C administered singly or in combination with other supplements, follow- up period, methodological quality, cancer mortality, gender, smoking status, country, and type of cancer also showed no efficacy of vitamin C supplementation for cancer prevention.
Conclusion: This meta-analysis shows that there is no evidence to support the use of vitamin C supplements for prevention of cancer.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bielski BH / 1975 / Some properties of the ascorbate free radical / Ann N Y Acad Sci 258 : 231 ~ 237
Bjelakovic G / 2008 / Systematic review:primary and secondary prevention of gastrointestinal cancers with antioxidant supplements / Aliment Pharmacol Ther 28 : 689 ~ 703
Buettner GR / 1993 / EPR spin trapping of free radicals produced by bleomycin and ascorbate / Free Radic Res Commun 19 (Suppl 1) : S89 ~ S93
Cameron E / 1974 / The orthomolecular treatment of cancer. I. The role of ascorbic acid in host resistance / Chem Biol Interact 9 : 273 ~ 283
Cameron E / 1974 / The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer / Chem Biol Interact 9 : 285 ~ 3
Bjelakovic G / 2008 / Systematic review:primary and secondary prevention of gastrointestinal cancers with antioxidant supplements / Aliment Pharmacol Ther 28 : 689 ~ 703
Buettner GR / 1993 / EPR spin trapping of free radicals produced by bleomycin and ascorbate / Free Radic Res Commun 19 (Suppl 1) : S89 ~ S93
Cameron E / 1974 / The orthomolecular treatment of cancer. I. The role of ascorbic acid in host resistance / Chem Biol Interact 9 : 273 ~ 283
Cameron E / 1974 / The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer / Chem Biol Interact 9 : 285 ~ 3
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